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Detection of Chemical, Biological, Radiological and Nuclear Agents for the Prevention of Terrorism pp 69–81Cite as

An Overview of Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry and Some of Its Applications

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Abstract

Matrix-assisted laser desorption/ionization time-of-flight (TOF) mass spectrometry (MS) is a powerful tool for both the qualitative and quantitative analysis of wide array of analytes. MALDI-TOF MS is simple, both in design and practice, and offers the advantages that analysis times are very short, the mass range is virtually unlimited, and sensitivity is high. This chapter describes the theory and practice of MALDI and illustrates the utility of approach by reviewing its common applications.

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Acknowledgements

We thank Dr Marvin Vestal and his colleagues at SimulTOF Systems, Sudbury, MA, for supplying the two figures that are included in this manuscript.

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Authors and Affiliations

  1. Proteomics Resource, Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia

    Mark W. Duncan, Afshan Masood & Hicham Benabdelkamel

  2. Northern Ireland Centre for Stratified Medicine, University of Ulster, Altnagelvin Hospital Campus, Londonderry, UK

    David Gibson

  3. Division of Endocrinology, Metabolism & Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

    Ryan Walsh

Authors
  1. Mark W. Duncan
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  2. David Gibson
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  3. Ryan Walsh
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  4. Afshan Masood
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  5. Hicham Benabdelkamel
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Corresponding author

Correspondence to Mark W. Duncan .

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Editors and Affiliations

  1. Fisheries and Oceans Canada, Science Branch, Special Projects and Memorial University of New Foundland, St. John's, Canada

    Joseph Banoub

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Duncan, M.W., Gibson, D., Walsh, R., Masood, A., Benabdelkamel, H. (2014). An Overview of Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry and Some of Its Applications. In: Banoub, J. (eds) Detection of Chemical, Biological, Radiological and Nuclear Agents for the Prevention of Terrorism. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9238-7_5

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