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mTOR and Regulation of Translation

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Translation and Its Regulation in Cancer Biology and Medicine

Abstract

The PI3K/AKT/mTOR pathway is implicated in various cellular events including translation, cell proliferation, growth and metabolism, and is frequently dysregulated in cancer. In this chapter, we unveil how the mTOR pathway regulates the translation machinery and how dysregulation of translation via this pathway participates in cancer biology. We also discuss the clinical and therapeutic importance of the control of translation by the mTOR signaling in various types of cancers.

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Authors and Affiliations

  1. Department of Biochemistry, Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada

    Yoshinori Tsukumo & Bruno Fonseca

  2. Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Quebec City, QC, Canada

    Mathieu Laplante

  3. Division of General Surgery, Department of Surgery, Faculty of Medicine, McGill University, Montreal, QC, Canada

    Armen Parsyan

  4. Helen Diller Family Comprehensive Cancer Center, Department of Urology, School of Medicine, University of California San Francisco, San Francisco, CA, USA

    Davide Ruggero

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  1. Yoshinori Tsukumo
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  2. Mathieu Laplante
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  3. Armen Parsyan
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  4. Davide Ruggero
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  5. Bruno Fonseca
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Correspondence to Yoshinori Tsukumo .

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  1. Surgery, McGill University, Montreal, Québec, Canada

    Armen Parsyan

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Tsukumo, Y., Laplante, M., Parsyan, A., Ruggero, D., Fonseca, B. (2014). mTOR and Regulation of Translation. In: Parsyan, A. (eds) Translation and Its Regulation in Cancer Biology and Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9078-9_15

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