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Structure and Function of Bacterial Cytochrome c Oxidases

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Book cover Cytochrome Complexes: Evolution, Structures, Energy Transduction, and Signaling

Part of the book series: Advances in Photosynthesis and Respiration ((AIPH,volume 41))

Summary

Cytochrome c oxidase or complex IV is the terminal enzyme of the aerobic respiratory chain performing the essential process of reducing molecular oxygen to water. The energy resulting from this reaction is exploited to drive proton pumping across the membrane, which in turn contributes to the generation of a proton motive force and the downstream synthesis of ATP. This chapter highlights current progress in the field of bacterial cytochrome c oxidase research from the perspective of the structural and functional characterisation of this family of essential enzymes.

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Abbreviations

ATP:

Adenosine tri-phosphate

CcO:

Cytochrome c oxidase

EPR:

Electron paramagnetic resonance

FTIR:

Fourier transform infra-red spectroscopy

HCO:

Heme copper oxidase

HiPIP:

High potential iron-sulfur protein

MD:

Molecular dynamics

NAD+ :

Nicotinamide adenine dinucleotide (oxidised form)

NADH:

Nicotinamide adenine dinucleotide (reduced form)

NMR:

Nuclear magnetic resonance

N-side:

Electrochemically negative side of the membrane

PDB:

Protein Data Bank

P-side:

Electrochemically positive side of the membrane

ROS:

Reactive oxygen species

SU:

Subunit

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Acknowledgments

J.A. Lyons is funded through an individual postdoctoral fellowship from the Danish Research Council for Natural Sciences. F. Hilbers is funded through the Danish Research Institute of Translational Neuroscience. M. Caffrey is supported through Science Foundation Ireland (12/IA/1255), COST Action CM1306 and the National Institutes of Health (P50GM073210, U54GM094599).

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Authors and Affiliations

  1. Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

    Joseph A. Lyons & Florian Hilbers

  2. School of Medicine and School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland

    Martin Caffrey

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  1. Joseph A. Lyons
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  2. Florian Hilbers
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  3. Martin Caffrey
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Correspondence to Martin Caffrey .

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  1. Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA

    William A. Cramer

  2. Department of Biology, University of Wisconsin-Oshkosh, Oshkosh, Wisconsin, USA

    Toivo Kallas

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Lyons, J.A., Hilbers, F., Caffrey, M. (2016). Structure and Function of Bacterial Cytochrome c Oxidases. In: Cramer, W., Kallas, T. (eds) Cytochrome Complexes: Evolution, Structures, Energy Transduction, and Signaling. Advances in Photosynthesis and Respiration, vol 41. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7481-9_16

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