Abstract
Although it is 75 years since relaxin was first described [1], and almost 20 years since the cDNA sequences encoding for rat, porcine and human relaxin were reported [2,3,4], the isolation and characterisation of the cognate receptor/s, despite extensive investigation [5,6], has to date defied elucidation. Since the receptor would appear to be the key to a fuller understanding of the molecular mechanisms of action of relaxin [6], which is fundamental for structure-based design of agonists and antagonists with therapeutic potential, new approaches for its isolation warrant investigation.
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Nice, E. et al. (2001). The use of biosensor technology to search for orphan biomolecules: towards the relaxin receptor. In: Tregear, G.W., Ivell, R., Bathgate, R.A., Wade, J.D. (eds) Relaxin 2000. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2877-5_50
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DOI: https://doi.org/10.1007/978-94-017-2877-5_50
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