Abstract
A prototype design for a microfluidic sample preconditioning module is presented that is capable of removing sedimenting particles from the product stream of an air sampler. This device is the first stage of a multi-stage sample preconditioning system intended for the isolation and preconcentration of chemical and biological warfare agents. The prototype device was fabricated using a laminate-based construction technique in which fluidic features are cut using a CO2 laser machining system. Continuous high specificity capture of 4 microspheres (simulating airborne particles of no interest) while passing 3μm blue polystyrene microspheres (simulating a warfare agent bacterium) downstream at a flow rate of 100μL/min was demonstrated.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
www.mesosystems.com), Mesosystems, Inc., The BioCapture BT-500 Air Sampler.
P. Yager, D. Bell, J.P. Brody, D. Qin, C.R. Cabrera, A. E. Kamholz and B.H. Weigl, “Applying microfluidic chemical analytical systems to imperfect samples”, Micro Total Analysis Systems ‘88, Banff, Canada, Kluwer Academic Publishers, (1998), 207–212.
Y. Gao, M.N. Myers, B.N. Barman and J.C. Giddings, “Continuous fractionation of glass microspheres by gravitational sedimentation in split-Flow thin (SPLITT) cells”, Particulate Science and Technology, 9, (1991), 105–118.
J.C. Giddings, M.H. Moon, P.S. Williams and M.N. Myers, “Particle size distribution by sedimentation/steric field-flow fractionation: development of a calibration procedure based on density compensation”, Analytical Chemistry, 63, (1991), 1366–1372.
J. Pazourek, P. Filip, F. Matulik and J. Chmelik, “Rapid separation of micron-sized particles by field-flow fractionation using earth’s gravitational field”, Separation Science and Technology, 28 (10), (1993), 1859–1873.
W. Kim, Y.H. Park, J.Y. Shin and D.W. Lee, “Size determination of diesel soot particles using flow and sedimentation field-flow fractionation”, Analytical Chemistry, 71, (1999), 3265–3272.
P.S. Williams, “Particle trajectories in field-flow fractionation and SPLITT fractionation channels”, Separation Science and Technology, 29 (1), (1994), 11–45.
J. Zhang, P.S. Williams, M.N. Myers and J.C. Giddings, “Separation of cells and cell-sized particles by continuous SPLITT fractionation using hydrodynamic lift forces”, Separation Science and Technology, 29 (18), (1994), 2493–2522.
M. Martin, “Theory of field flow fractionation”, Advances in Chromatography, 39, (1998), 1–138.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer Science+Business Media Dordrecht
About this paper
Cite this paper
Hoii, M.R., Macounova, K., Yager, P. (2000). A Microfluidic Sedimentation Particulate Capture Device with Internal Degassing Membranes. In: van den Berg, A., Olthuis, W., Bergveld, P. (eds) Micro Total Analysis Systems 2000. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2264-3_73
Download citation
DOI: https://doi.org/10.1007/978-94-017-2264-3_73
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-5496-8
Online ISBN: 978-94-017-2264-3
eBook Packages: Springer Book Archive