Skip to main content

Enzyme Reactor Performance Under Thermal Inactivation

  • Chapter
Advances in Bioprocess Engineering

Abstract

Enzymes are labile catalysts when used under harsh process conditions. Modelling enzyme inactivation under operation is therefore relevant for the design and evaluation of enzyme reactor performance. A model is presented to describe thermal enzyme inactivation under protection by reaction effecters and applied to develop equations to describe reactor performance. Two case studies are presented: batch reactor with immobilized penicillin acylase and packed-bed continuous reactor with immobilized lactase.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

Literature Cited

  1. Henley, J. and A. Sadana. Biotechnol. Bioeng. 28, 1277 (1986).

    Article  PubMed  CAS  Google Scholar 

  2. Chen, K. and J. Wu. Biotechnol.Bioeng. 30, 817 (1987).

    Article  PubMed  CAS  Google Scholar 

  3. Alvaro, G., Fernândez-Lafuente, R., Blanco, R. and J. Guisân. Enzyme Microb. Technol. 13, 210 (1991).

    Article  PubMed  CAS  Google Scholar 

  4. Erarslans, A. and H. Kocer. J.Chem. Technol.Biotechnol. 55 79 (1992).

    Article  Google Scholar 

  5. Dubey, A., Bisaria, V., Mukhopadhyay, S. and T. Ghose.Biotechnol.Bioeng. 33, 1311 (1989).

    Article  CAS  Google Scholar 

  6. Dagys, R., Pauliokonis, A. and D. Kazlauskas. Biotechnol.Bioeng. 26, 620 (1984).

    Article  PubMed  CAS  Google Scholar 

  7. Henley, J. and A. Sadana. Enzyme Microb. Technol. 6, 35 (1984).

    Article  CAS  Google Scholar 

  8. O’Neill, S. Biotechnol.Bioeng. 14, 473 (1972).

    Article  PubMed  Google Scholar 

  9. Park, M., Choi, C., Han, M. and B. Seong. Biotechnol.Bioeng. 24, 1623 (1982).

    Article  PubMed  CAS  Google Scholar 

  10. Warburton, D., Dunnill, P. and M. Lilly. Biotechnol.Bioeng. 15, 13 (1973).

    Article  CAS  Google Scholar 

  11. Vandamme, E. Immobilized biocatalyst and antibiotic production, In: M. Moo-Young (Ed), Bioreactor ImmobilizedEnzymes and Cells, Elsevier AppliedScience, London, pp. 281–286 (1988).

    Google Scholar 

  12. Illanes, A., Ruiz, A., Vâsquez, M. and R. Torres. Caracterización cinética de penicilina acilasa de Bacillus megaterium inmovilizada en quitina. Proc. 3rd. Latinamerican Congress of Biotechnology, Santiago, Chile, p. 223 (1993).

    Google Scholar 

  13. Illanes, A., Cartagena, O. and R. Conejeros. Reactor design for penicillin acylase under thermal inactivation. Proc. Ninth International Biotechnology Symposium, Crystal City, USA, NP 596(1992).

    Google Scholar 

  14. Illanes, A., Ruiz, A., Zdhiga, M., Aguirre, C., O’Reilly, S. and E. Curotto. Bioproc. Eng. 5, 257 (1990).

    Article  CAS  Google Scholar 

  15. Illanes, A., Zdhiga, M. and A. Ruiz. Arch.Biol.Med.Exp. 23, 159 (1990).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Illanes, A., Altamirano, C., Cartagena, O. (1994). Enzyme Reactor Performance Under Thermal Inactivation. In: Galindo, E., Ramírez, O.T. (eds) Advances in Bioprocess Engineering. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0641-4_64

Download citation

  • DOI: https://doi.org/10.1007/978-94-017-0641-4_64

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-4459-4

  • Online ISBN: 978-94-017-0641-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics