Abstract
The development of a fluidized bed reactor for animal cell culture is described. Using both solid (Polysciences) and porous (Siran) glass beads, BHK cells have been grown to densities of 4x107 cells ml−1. Using external-loop oxygenation, the accurate measurements of online oxygen uptake rates were possible, which correlated well with the changing reactor conditions, as well as with the glucose and lactate uptake rates.
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Literature Cited
Keller, J., M. Murkovic, I.J. Dunn, E.Heinzle,J.Prenosil, DECHEMA Biotechnology Conferences, 3, 1989, 715
J. Keller, Dissertation, No. 9373,the porous glass carrier. ETH-Zurich, 1991
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© 1994 Springer Science+Business Media Dordrecht
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Keller, J., Dunn, I.J. (1994). A Fluidized Bed Reactor for the Cultivation of Animal Cells. In: Galindo, E., Ramírez, O.T. (eds) Advances in Bioprocess Engineering. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0641-4_16
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DOI: https://doi.org/10.1007/978-94-017-0641-4_16
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-4459-4
Online ISBN: 978-94-017-0641-4
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