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The role of macrophage-derived growth factors in tissue repair

  • Chapter
Mononuclear Phagocytes

Abstract

Macrophages, which are required for wound healing (1, 2), are the central player in the repair of tissue injury. When macrophages are eliminated by anti-leukocyte serum injected locally, and monocyte production is prevented by injection of glucocorticoids, wound healing proceeds very slowly. It is likely that macrophages participate in most processes in wound healing, from acute and chronic inflammation through recruitment of new blood vessels (angiogenesis), proliferation of endothelial and mesenchymal cells and regulation of extracellular matrix synthesis and degradation.

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Authors
  1. Z. Werb
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  2. J. L. Underwood
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  3. D. A. Rappolee
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Editor information

Editors and Affiliations

  1. Department of Infectious Diseases, University Hospital Leiden, The Netherlands

    Ralph van Furth

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© 1992 Springer Science+Business Media Dordrecht

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Werb, Z., Underwood, J.L., Rappolee, D.A. (1992). The role of macrophage-derived growth factors in tissue repair. In: van Furth, R. (eds) Mononuclear Phagocytes. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-8070-0_54

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  • DOI: https://doi.org/10.1007/978-94-015-8070-0_54

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-4171-5

  • Online ISBN: 978-94-015-8070-0

  • eBook Packages: Springer Book Archive

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