Abstract
Lithium has a relatively narrow therapeutic range. Dosages necessary for therapy and prophylaxis are not very much lower than those that may produce poisoning, and occasionally patients who have been given lithium for a long time without signs of intolerance may accumulate lithium and develop intoxication. Lithium poisoning is a serious condition, which may lead to death or to permanent sequelae, but it does not develop haphazardly and without warning. Experience has shown that various circumstances involve extra risk of lithium poisoning and that countermeasures may be taken. Furthermore, lithium poisoning is usually heralded by particular signs and symptoms; if these are detected at an early stage, progression of the intoxication may be prevented.
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References
Thomsen, K., Olesen, O. V., Jensen, J. and Schou, M. (1976). Mechanism of gradually developing lithium intoxication in rats. In Essman, W. B. and Valzelli, L. (eds.): Current Developments in Psychopharmacology, 3, 156–177. Spectrum Publications: New York.
Thomsen, K. and Olesen, O. V. (1978). Precipitating factors and renal mechanisms in lithium intoxication. Gen. Pharmacol., 9, 85–89.
Hansen, H. E. and Amdisen, A. (1978). Lithium intoxication. (Report of 23 cases and review of 100 cases from the literature.) Q. J. Med., N. Ser., 47, 123–144.
Granoff, A. L. and Davis, J. M. (1978). Heat illness syndrome and lithium intoxication.J. Clin. Psychiat., 39, 103–107.
Speirs, J. and Hirsch, S. R. (1978). Severe lithium toxicity with’normal’serum concentrations. Br. Med. J., 2, 815–816.
Pedersen, R. S. and Svendsen, O. (1976). Lithiumforgiftning behandlet med haemodialyse. Ugeskr. Log., 138, 3325–3327.
Amdisen, A. (1975). Monitoring of lithium treatment through determination of the lithium concentration. Dan. Med. Bull., 22, 277–291.
Krakower, J. M. (1978). Transient aphasia with lithium toxicity. Psychosom., 19, 25–26.
McGennis, A. J. (1978). Lithium carbonate and tetracycline interaction. Br. Med. J., 2, 1183.
Thomsen, K. and Olesen, O. V. (1979). The effect of water deprivation on lithium clearance and lithium excretion fraction in lithium-polyuric rats J. Pharmacol. Exp. Ther., 209, 327–329.
Olesen, O. V. and Thomsen, K.(1976). A preventive effect of potassium against fatal lithium intoxication in rats. Neuropsychobiol., 2, 112–117.
Amdisen, A. (1978). Clinical and serum-level monitoring in lithium therapy and lithium intoxication. J. Anal. Toxicol., 2, 193–202.
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Schou, M. (1980). The Recognition and Management of Lithium Intoxication. In: Johnson, F.N. (eds) Handbook of Lithium Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7197-7_45
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DOI: https://doi.org/10.1007/978-94-011-7197-7_45
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-011-7199-1
Online ISBN: 978-94-011-7197-7
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