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Detection of intrapulmonary vasodilatation and diagnosis of hepatopulmonary syndrome using contrast echocardiography

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Advances in Echo Imaging Using Contrast Enhancement
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Abstract

The hepatopulmonary syndrome is defined by a triad including liver disease and/or portal hypertension, gas exchange abnormalities (arterial pO2 < 70 mmHg or alveolar— arterial gradient >20mmHg) and intrapulmonary vasodilatation. The mainstay of diagnosis of this syndrome is the detection of intrapulmonary vasodilatation. Contrast echocardiography (CE) and lung perfusion scanning (Tc99-MAA) are the current modalities utilized to detect intrapulmonary vasodilatation and to diagnose hepatopulmonary syndrome (HPS). This chapter will briefly review the HPS and focus on the use of CE in diagnosis as well as potential future diagnostic modalities.

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References

  1. Fluckiger M. Vorkommen von trommelschagelformigen Fingerendphalangen ohne chronische Veranderungen an den Lungen oder am Herzen. Wien Med Wchnschr 1884;34:1457.

    Google Scholar 

  2. Rydell R, Hoflbauer FW. Multiple pulmonary arteriovenous fistulas in juvenile cirrhosis. Am J Med 1956;21:450.

    Article  PubMed  Google Scholar 

  3. Calabresi P, Abelmann WH. Portocaval and porto-pulmonary anastomoses in Lannec’s cirrhosis and in heart failure. J Clin Invest 1957;36:1257–65.

    Article  PubMed  CAS  Google Scholar 

  4. Berthelot P, Walter JG, Sherlock S, Reid L. Arterial changes in the lungs in cirrhosis of the liver-lung spider nevi. N Engl J Med 1966;274:291–8.

    Article  PubMed  CAS  Google Scholar 

  5. Krowka MJ, Cortese DA. Pulmonary aspects of liver disease and liver transplantation. Clin Chest Med 1989;10:593–616.

    PubMed  CAS  Google Scholar 

  6. Stanley NN, Williams AJ, Dewar CA et al. Hypoxia and hydrothorax in a case of liver cirrhosis:correlation of physio-logical, radiographic, scintigraphic and pathological findings. Thorax 1977;32:457.

    Article  PubMed  CAS  Google Scholar 

  7. Davis HH, Schwartz DJ, Lefrak SS, Susanan N, Schainker BA. Alveolar-capillary oxygen disequilibrium in hepatic cirrhosis. Chest 1978;73:507–11.

    Article  PubMed  Google Scholar 

  8. Williams A, Trewby P, Williams R, Reid L. Structural alterations to the pulmonary circulation in fulminant hepatic failure. Thorax 1979;34:447–53.

    Article  PubMed  CAS  Google Scholar 

  9. Kennedy TC, Knudson RJ. Exercise aggregated hypoxemia and orthodeoxia in cirrhosis. Chest 1977;72:305.

    Article  PubMed  CAS  Google Scholar 

  10. Daoud F, Reeves J, Schaefer JW. Failure of hypoxic pulmonary vasoconstriction in patients with liver cirrhosis. J Clin Invest 1972;51:1076–80.

    Article  PubMed  CAS  Google Scholar 

  11. Naeije R, Melot C, Hallemans R et al. Pulmonary hemodynamics in liver cirrhosis. Sem Resp Med. 1985;7:164.

    Article  Google Scholar 

  12. Rodriguez-Roisin R, Roca J, Augusti A, Mastai R, Wagner P, Bosch J. Gas exchange and pulmonary vascular reactivity in patients with liver cirrhosis. Am Rev Resp Dis 1987;135:1085–92.

    PubMed  CAS  Google Scholar 

  13. Genovisi MG, Tierney DF, Taplin GV, Eisenberg H. An intravenous radionuclide method to evaluate hypoxemia caused by abnormal alveolar vessels. Am Rev Resp Dis 1976;114:59–65.

    Google Scholar 

  14. Lange P, Stoller J. The hepatopulmonary syndrome. Ann Intern Med 1995;122:521–9.

    PubMed  CAS  Google Scholar 

  15. Abrams GA, Jaffe C, Hoffer PB, Binder HJ, Fallon MB. Diagnostic utility of contrast echocardiography and lung perfusion scan in patients with hepatopulmonary syndrome. Gastroenterology 1995;109:1283–8.

    Article  PubMed  CAS  Google Scholar 

  16. Fallon MB, Abrams GA, Chen YF et al. Altered pulmonary expression of vasoactive mediators in a rat model of hepatopulmonary syndrome. Hepatology 1995;22:221A.

    Google Scholar 

  17. Krowka MJ, Cortese DA. Severe hypoxemia associated with liver disease:Mayo Clinic experience and the experimental use of almitrine bismesylate. Mayo Clin Proc 1987;62:164–73.

    Article  PubMed  CAS  Google Scholar 

  18. Nakos G, Evrenoglu D, Vassilakis N et al. Haemodynamics and gas exchange in liver cirrhosis:the effect of orally administered almitrine bismesylate. Resp Med 1993;87:93–8.

    Article  CAS  Google Scholar 

  19. Krowka MJ, Dickson ER, Cortese DA. Hepatopulmonary syndrome:Clinical observations and lack of therapeutic response to somatostatin analogue. Chest 1993;104:515–21.

    Article  PubMed  CAS  Google Scholar 

  20. Schwartz SM, Pound DC. Hepatopulmonary syndrome:failure of response to somatostatin analogue. Gastroenterology 1992;102:882A.

    Google Scholar 

  21. Hobeika J, Houssin D, Bernard O et al. Orthotopic liver transplantation in children with chronic liver disease and severe hypoxemia. Transplantation 1994;57:224–8.

    Article  PubMed  CAS  Google Scholar 

  22. Shijo H, Sasaki H, Yuh K et al. Effects of indomethacin on hepatogenic pulmonary angiodysplasia. Chest 1991;99:1027–9.

    Article  PubMed  CAS  Google Scholar 

  23. Caldwell SH, Jeffers LJ, Narula OS et al. Ancient remedies revisited:does Allium sativum(garlic) palliate the hepatopulmonary syndrome? J Clin Gastroenterol 1992;15:248–50.

    Article  PubMed  CAS  Google Scholar 

  24. Abrams GA, Krowka MJ, Crapo RO, Fallon MB. Hepatopulmonary syndrome. Open label trial with Allium sativum(garlic). Hepatology 1995;22:167A.

    Google Scholar 

  25. Van Obbergh L, Carlier M, De Clety S et al. Liver transplantation and pulmonary gas exchange in hypoxemic children. Am Rev Resp Dis 1993;148:1408–10.

    PubMed  Google Scholar 

  26. Gramiak R, Shah P, Kramer D. Ultrasound cardiography. Contrast studies in anatomy and function. Radiology 1968;92:939.

    Google Scholar 

  27. Meltzer RS, Tickner EG, Popp RL. Why do lungs clear ultrasonic contrast? Ultrasound Med Biol 1980;6:263–9.

    Article  PubMed  CAS  Google Scholar 

  28. Shub C, Tajik AJ, Seward JB, Dines DE. Detecting intrapulmonary right to left shunt with contrast echocardiography. Mayo Clin Proc 1976;51:81–4.

    PubMed  CAS  Google Scholar 

  29. Hind C, Wong C. Detection of pulmonary arteriovenous fistulae in patient with cirrhosis by contrast 2D echocardiography. Gut 1981;22:1042–5.

    Article  PubMed  CAS  Google Scholar 

  30. Krowka MJ, Tajik Ai, Dickson ER, Wiesner RH, Cortese DA. Intrapulmonary vascular dilatations (IPVD) in liver transplant candidates. Screening by two-dimensional contrast-enhanced echocardiography. Chest 1990;97:1165–70.

    Article  PubMed  CAS  Google Scholar 

  31. Hopkins WE, Waggoner BA, Barzilai B. Frequency and significance of intrapulmonary rightto-left shunting in end-stage hepatic disease. Am J Cardiol 1992;70:516–9.

    Article  PubMed  CAS  Google Scholar 

  32. Rodriguez L, Lange P, Garcia M, Lombardo H, Stoller JK, Thomas JD. Positive echo-contrast does not correlate with physiologic shunt studies in patients with severe liver disease. J Am Coll Cardiol 1994:25A.

    Google Scholar 

  33. Kures PR, Soble JS, Nermann A et al. Frequency of intrapulmonary right to left shunt detected by contrast echocardiography in advanced liver disease (abstr). J Am Soc Echocardiogr 1994;7:27E.

    Google Scholar 

  34. Robin ED, Horn B, Goris ML et al. Detection, quantitation and pathophysiology of lung spiders. Clin Res 1975;23:448.

    Google Scholar 

  35. Fallon M, Abrams G, Hou Z, Luo B. Intrapulmonary vasodilatation occurs in a rat model of hepatopulmonary syndrome. Gastroenterology 1996;110:A1188.

    Google Scholar 

  36. Nanda N. Echocontrast enhancers —how safe are they? In:Nanda N, Schlief R, eds. Advances in Echo Imaging using Contrast Enhancement. 1st edn. Dordrecht:KluwerAcademic Publishers, 1993:97–110.

    Google Scholar 

  37. Brucher R, Russell D. Embolus detection with Doppler ultrasonography —background and principles. In:Tegeler C, Babikian V, Gomez C, eds. Neurosonology. St. Louis:Mosby-Year Book Inc., 1996:231–4.

    Google Scholar 

  38. Russell D, Brucher R, Madden K. The intensity of the Doppler signal caused by arterial emboli depends on embolus size. In:Oka M, Reutern GV, Furuhata H, Kodaira K, eds. Recent Advances in Neurosonology:Proceedings of the Fourth Meeting of the Neurosonology Research Group of the World Federation of Neurology. Amsterdam:Exerpta Medica, 1992:57–60.

    Google Scholar 

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© 1997 Springer Science+Business Media Dordrecht

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Abrams, G.A., Fallon, M.B., Gomez, C.R., Nanda, N.C. (1997). Detection of intrapulmonary vasodilatation and diagnosis of hepatopulmonary syndrome using contrast echocardiography. In: Nanda, N.C., Schlief, R., Goldberg, B.B. (eds) Advances in Echo Imaging Using Contrast Enhancement. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5704-9_16

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  • DOI: https://doi.org/10.1007/978-94-011-5704-9_16

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6405-7

  • Online ISBN: 978-94-011-5704-9

  • eBook Packages: Springer Book Archive

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