Abstract
The solubilizing potential and complexing tendencies of six cyclodextrins (CyD) with nifedipine in aqueous solution were evaluated using phase solubility methods. Solubility curves of nifedipine with β-CyD, 2-hydroxypropyl-β-CyD (2HP-β-CyD) and 2-hydroxypropyl-γ-cyclodextrin (2HP-γ-CyD) were classified as type AL, while for heptakis (2, 6-dimethyl)β-CyD (DIMEB), randomly methylated-β-CyD (RAMEB) and γ-CyD, AP type phase behaviour was observed. Stability constants, calculated from phase solubility diagrams, decreased in the order: DIMEB > RAMEB > β-CyD > 2HP-β-CyD > γ-CyD > 2HP-γ-CyD.
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© 1996 Springer Science+Business Media Dordrecht
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Worthington, M.S., Glass, B.D., Penkler, L.J. (1996). Phase Solubility Analysis in Studying the Interaction of Nifedipine with Selected Cyclodextrins in Aqueous Solution. In: Szejtli, J., Szente, L. (eds) Proceedings of the Eighth International Symposium on Cyclodextrins. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5448-2_72
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DOI: https://doi.org/10.1007/978-94-011-5448-2_72
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