Abstract
Different batches of ethylated derivatives of β-cyclodextrins (Et-βCD) obtained by various synthetic routes were used as host molecules to prepare inclusion compounds of salbutamol. Previous results showed that these complexes were suitable to achieve variable sustained-release behaviour of salbutamol. The mechanism of sustained-release was related to the inclusion capacity and physicochemical properties of Et-βCD. Among the various analytical techniques carried out to characterize them, high resolution NMR afforded relevant information in terms of degree and patterns of subtitution, which could explain the differences observed between CD derivatives.
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References
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Lemesle-Lamache, V., Wouessidjewe, D., Chéron, M., Duchêne, D., Study of β-cyclodextrin and ethylated β-cyclodextrin salbutamol complexes, in vitro evaluation of sustained-release behaviour of salbutamol, Int. J. Pharm., submitted..
Lemesle-Lamache, V., Wouessidjewe, D., Taverna, M., Ferrier, D., Perly, B., Duchêne, D., Physicochemical characterization of different batches of ethylated β-cyclodextrins, J. Pharm. Sci., submitted..
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© 1996 Springer Science+Business Media Dordrecht
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Wouessidjewe, D., Lemesle-Lamache, V., Duchene, D., Perly, B. (1996). Influence of Degree and Patterns of Substitution on the Inclusion Properties of Ethylated β-Cyclodextrins. In: Szejtli, J., Szente, L. (eds) Proceedings of the Eighth International Symposium on Cyclodextrins. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5448-2_47
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DOI: https://doi.org/10.1007/978-94-011-5448-2_47
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6291-6
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