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The Synthesis of Oligosaccharide-Branched Cyclodextrins and their Interaction with Concanavalin A

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Proceedings of the Eighth International Symposium on Cyclodextrins

Abstract

New oligosaccharide-branched β-cyclodextrins having a various oligosaccharides in a primary hydroxyl group of β-cyclodextrin(CD) were synthesized and examined for the interaction with the immobilized concanavalin A(ConA) compared with 6-O-glucosyl and maltosyl CD. Oligosaccharides were converted to lactones at the reducing end, which was connected with 6-monoamino-β-CD forming an amide bond. For the analysis of the interaction between ConA immobilized on an aminosilane-hydrogel surface and various oligosaccharide CDs, a biosensor of the FISONS IAsys apparatus based on a resonant mirror detector (RMD) was used. As a result, it interacted with immobilized ConA and both maltosyl-β-CD(3) and maltosyl-γ-CD(6), and glucosylglucono-amide-β-CD(7) with the association constants, Ka of 134, 833 and 8730 M−1, respectively.

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Author information

Authors and Affiliations

  1. Faculty of Engineering, Tokyo Institute of Polytechnics, 1583 Iiyama, Atsugi, Kanagawa, 243-02, Japan

    Kenjiro Hattori, Hideo Imata, Kohji Kubota & Keisuke Matsuda

  2. Scientific Instrument Sales Laboratory, Nissei Sangyo Co., Ltd., 20-1 Morinosato Aoyama, Atsugi, Kanagawa, 243-01, Japan

    Masaaki Aoyagi, Keiko Yamamoto & Chiaki Jindoh

  3. The Noguchi Institute, 1-8-1 Kaga, Itabashi-ku, Tokyo, 173, Japan

    Takashi Yamanoi & Toshiyuki Inazu

Authors
  1. Kenjiro Hattori
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  2. Hideo Imata
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  3. Kohji Kubota
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  4. Keisuke Matsuda
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  5. Masaaki Aoyagi
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  6. Keiko Yamamoto
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  7. Chiaki Jindoh
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  8. Takashi Yamanoi
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  9. Toshiyuki Inazu
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Editor information

Editors and Affiliations

  1. Cyclolab, Cyclodextrin Research and Development Laboratory Ltd., Budapest, Hungary

    J. Szejtli  & L. Szente  & 

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© 1996 Springer Science+Business Media Dordrecht

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Hattori, K. et al. (1996). The Synthesis of Oligosaccharide-Branched Cyclodextrins and their Interaction with Concanavalin A. In: Szejtli, J., Szente, L. (eds) Proceedings of the Eighth International Symposium on Cyclodextrins. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5448-2_25

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  • DOI: https://doi.org/10.1007/978-94-011-5448-2_25

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6291-6

  • Online ISBN: 978-94-011-5448-2

  • eBook Packages: Springer Book Archive

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