Skip to main content

Helicobacter pylori and gastroduodenal secretions

  • Chapter
Helicobacter pylori
  • 179 Accesses

Abstract

This chapter aims to give a short update on Helicobacter pylori-induced effects on gastric acid and duodenal bicarbonate secretions, and how these disturbances may participate in the development of duodenal ulcer disease. It is not intended to be a full review, but rather a subjectively selected update with some personal speculations.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Hunt RH. Campylobacter pylori and spontaneous hypochlorhydria. In: Rathbone BJ, Heatley RV, editors. Campylobacter pylori and Gastroduodenal Disease. London: Blackwell;1989:176–84.

    Google Scholar 

  2. Levi S, Beardshall K, Haddad G, Playford R, Ghosh P, Calam J. Campylobacter pylori and duodenal ulcers: the gastrin link. Lancet 1989;1:1167–8.

    Article  PubMed  CAS  Google Scholar 

  3. Graham DY, Opekun A, Lew GM, Klein PD, Walsh JH. Helicobacter pylori-associated exaggerated gastrin release in duodenal ulcer patients. The effect of bombesin infusion and urea ingestion. Gastroenterology. 1991;100:1571–5.

    PubMed  CAS  Google Scholar 

  4. Beardshall K, Moss SF, Gill J et al. Suppression of Helicobacter pylori reduces gastrin-releasing peptide stimulated gastrin release in duodenal ulcer patients. Gut. 1992;33:601–3.

    Article  PubMed  CAS  Google Scholar 

  5. Moss SF, Legon S, Bishop AE, Polak JM, Calam J. Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease. Lancet. 1992;340:930–2.

    Article  PubMed  CAS  Google Scholar 

  6. Gibbons AH, Legon S, Walker MM, Ghatei M, Calam J. The effect of gastrin-releasing peptide on gastrin and somatostatin messenger RNAs in humans infected with Helicobacter pylori. Gastroenterology. 1997;112:1940–7.

    Article  PubMed  CAS  Google Scholar 

  7. Zaki M, Harrington L, McCuen R, Coy DH, Arimura A, Schubert ML. Somatostatin receptor subtype 2 mediates inhibition of gastrin and histamine secretion from human, dog, and rat antrum. Gastroenterology. 1996;111:919–24.

    Article  PubMed  CAS  Google Scholar 

  8. Beales I, Blaser MJ, Srinivasan S et al. Effect of Helicobacter pylori products and recombinant cytokines on gastrin release from cultured canine G cells. Gastroenterology. 1997;113:465–71.

    Article  PubMed  CAS  Google Scholar 

  9. Olbe L, Hamlet A, Dalenbäck J, Fändriks L. A mechanism by which Helicobacter pylori infection of the antrum contributes to the development of duodenal ulcer. Gastroenterology. 1996;110:1386–94.

    Article  PubMed  CAS  Google Scholar 

  10. Schubert ML, Makhlouf GM. Neural, hormonal, and paracrine regulation of gastrin and acid secretion. Yale J Biol Med. 1992;65:553–60.

    PubMed  CAS  Google Scholar 

  11. Schmidt P, Poulsen SS, Hilsted L, Rasmussen TN, Holst JJ. Tachykinins mediate vagal inhibition of gastrin secretion in pigs. Gastroenterology. 1996;111:925–35.

    Article  PubMed  CAS  Google Scholar 

  12. El-Omar E, Penman I, Dorrian CA, Ardill JES, McColl KEL. Eradicating Helicobacter pylori infection lowers gastrin-mediated acid secretion by two-thirds in duodenal ulcer patients. Gut. 1993;34:1060–5.

    Article  PubMed  CAS  Google Scholar 

  13. Chittajallu RS, Howie CA, McColl KEL. Effect of Helicobacter pylori on parietal cell sensitivity to pentagastrin in duodenal ulcer patients. Scand J Gastroenterol. 1992;27:857–62.

    Article  PubMed  CAS  Google Scholar 

  14. Peterson WL, Barnett CC, Evans DJ Jr et al. Acid secretion and serum gastrin in normal subjects and patients with duodenal ulcer: the role of Helicobacter pylori. Am J Gastroenterol. 1993;88:2038–43.

    PubMed  CAS  Google Scholar 

  15. Tarnasky PR, Kovacs TOG, Sytnik B, Walsh JH. Asymptomatic H. pylori infection impairs pH inhibition of gastrin and acid secretion during second hour of peptone meal stimulation. Dig Dis Sci. 1993;38:1681–7.

    Article  PubMed  CAS  Google Scholar 

  16. Hamlet A, Olbe L. The influence of Helicobacter pylori infection on post-prandial duodenal acid load and duodenal bulb pH in humans. Gastroenterology. 1996;111:391–400.

    Article  PubMed  CAS  Google Scholar 

  17. Kihl B, Olbe L. Inhibition of pentagastrin-stimulated gastric acid secretion by intraduodenal administration of graded doses of oleic acid in man. Scand J Gastroenterol. 1981;16:121–8.

    Article  PubMed  CAS  Google Scholar 

  18. Hamlet A, Lindholm C, Nilsson O, Olbe L. Aspirin-like Helicobacter pylori induced gastritis disinhibits acid secretion in humans; relation to cytokine expression. Scand J Gastroenterol. 1998 (In press).

    Google Scholar 

  19. Harris AW, Gummett PA, Walker MM, Misiewicz JJ, Baron JH. Relation between gastric acid output, Helicobacter pylori, and gastric metaplasia in the duodenal bulb. Gut. 1996;39:513–20.

    Article  PubMed  CAS  Google Scholar 

  20. Savarino V, Mela GS, Zentilin P et al. 24-hour gastric pH and extent of duodenal gastric metaplasia in Helicobacter pylori-positive patients. Gastroenterology. 1997;113:741–5.

    Article  PubMed  CAS  Google Scholar 

  21. Wyatt JI, Rathbone BJ, Sobala GM et al. Gastric epithelium in the duodenum: its association with Helicobacter pylori and inflammation. J Clin Pathol. 1990;43:981–6.

    Article  PubMed  CAS  Google Scholar 

  22. Hamlet A, Thoreson A-C, Nilsson O, Svennerholm A-M, Olbe L. Duodenal Helicobacter pylori infection differs between asymptomatic carriers and duodenal ulcer patients. (Submitted).

    Google Scholar 

  23. Noach LA, Rolf TM, Bosma NB et al. Gastric metaplasia and Helicobacter pylori infection. Gut. 1993;34:1510–14.

    Article  PubMed  CAS  Google Scholar 

  24. Atherton LP, Tham KT, Peek RM Jr, Cover TL, Blaser MJ. Density of Helicobacter pylori infection in vivo as assessed by quantitative culture and histology. J Infect Dis. 1996;174:552–6.

    Article  PubMed  CAS  Google Scholar 

  25. Censini S, Lange C, Xiang Z et al. cag, a pathogenicity island of Helicobacter pylori, encodes type 1-specific and disease-associated virulence factors. Proc Natl Acad Sci USA. 1996; 93:14648–53.

    Article  PubMed  CAS  Google Scholar 

  26. Bilski J, Konturek SJ. Role of nitric oxide in gastroduodenal alkaline secretion. J Physiol Pharmacol. 1994;45:541–53.

    PubMed  CAS  Google Scholar 

  27. Takeuchi K, Ohuchi T, Miyake H, Okabe S. Stimulation by nitric oxide synthase inhibitors of gastric and duodenal HCO3 secretion in rats. J Pharmacol Exp Ther. 1993;266:1512–19.

    PubMed  CAS  Google Scholar 

  28. Holm M, Johansson B, von Bothmer C, Jönson C, Pettersson A, Fändriks L. Acid-induced increase in duodenal mucosal alkaline secretion in the rat involves the L-arginine/NO pathway. Acta Physiol Scand. 1997;161:527–32.

    Article  PubMed  CAS  Google Scholar 

  29. Tepperman BL, Brown JF, Whittle BJR. Nitric oxide synthase induction and intestinal epithelial cell viability in rats. Am J Physiol. 1993;265:G214–18.

    PubMed  CAS  Google Scholar 

  30. Takeuchi K, Matsumoto J, Ueshima K, Okabe S. Role of capsaicin-sensitive afferent neurons in alkaline secretory response to luminal acid in the rat duodenum. Gastroenterology. 1991;101:954–61.

    PubMed  CAS  Google Scholar 

  31. Hamlet A, Jönson C, Fändriks L. The mediation of increased duodenal alkaline secretion in response to 10 mM HC1 in the anaesthetized rat. Support for the involvement of capsaicinsensitive nerve elements. Acta Physiol Scand. 1992;146:519–25.

    Article  PubMed  CAS  Google Scholar 

  32. Holm M, Johansson B, Pettersson A, Fändriks L. Acid-induced duodenal mucosal NO output parallels bicarbonate secretion in the anaesthetized pig. Acta Physiol Scand. (In press).

    Google Scholar 

  33. Isenberg JI, Selling JA, Hogan DL, Koss MA. Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer. N Engl J Med. 1987;316:374–9.

    Article  PubMed  CAS  Google Scholar 

  34. Hogan DL, Rapier RC, Dreilinger A et al. Duodenal bicarbonate secretion: eradication of Helicobacter pylori and duodenal structure and function in humans. Gastroenterology. 1996;110:705–16.

    Article  PubMed  CAS  Google Scholar 

  35. Fändriks L, von Bothmer C, Johansson B, Holm M, Bölin I, Pettersson A. Water extract of Helicobacter pylori inhibits duodenal mucosal alkaline secretion in anesthetized rats. Gastroenterology. 1997;113:1570–5.

    Article  PubMed  Google Scholar 

  36. Fändriks L, von Bothmer C, Lönroth H, Olbe L, Pettersson A. Presence of the NO-synthase inhibitor ADMA in H. pylori -infected antral mucosa. Abstract, DDW, New Orleans. 1998.

    Google Scholar 

  37. Karita M, Tummuru MKR, Wirth H-P, Blaser MJ. Effect of growth phase and acid shock on Helicobacter pylori cagA expression. Infect Immun. 1996;64:4501–7.

    PubMed  CAS  Google Scholar 

  38. Wallace JL, Keenan CM, Granger DN. Gastric ulceration induced by non-steroidal drugs is a neutrophil-dependent process. Am J Physiol. 1990;259:G462–7.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Olbe, L., Hamlet, A., Fändriks, L. (1998). Helicobacter pylori and gastroduodenal secretions. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4882-5_17

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-4882-5_17

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6046-2

  • Online ISBN: 978-94-011-4882-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics