Abstract
This chapter aims to give a short update on Helicobacter pylori-induced effects on gastric acid and duodenal bicarbonate secretions, and how these disturbances may participate in the development of duodenal ulcer disease. It is not intended to be a full review, but rather a subjectively selected update with some personal speculations.
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References
Hunt RH. Campylobacter pylori and spontaneous hypochlorhydria. In: Rathbone BJ, Heatley RV, editors. Campylobacter pylori and Gastroduodenal Disease. London: Blackwell;1989:176–84.
Levi S, Beardshall K, Haddad G, Playford R, Ghosh P, Calam J. Campylobacter pylori and duodenal ulcers: the gastrin link. Lancet 1989;1:1167–8.
Graham DY, Opekun A, Lew GM, Klein PD, Walsh JH. Helicobacter pylori-associated exaggerated gastrin release in duodenal ulcer patients. The effect of bombesin infusion and urea ingestion. Gastroenterology. 1991;100:1571–5.
Beardshall K, Moss SF, Gill J et al. Suppression of Helicobacter pylori reduces gastrin-releasing peptide stimulated gastrin release in duodenal ulcer patients. Gut. 1992;33:601–3.
Moss SF, Legon S, Bishop AE, Polak JM, Calam J. Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease. Lancet. 1992;340:930–2.
Gibbons AH, Legon S, Walker MM, Ghatei M, Calam J. The effect of gastrin-releasing peptide on gastrin and somatostatin messenger RNAs in humans infected with Helicobacter pylori. Gastroenterology. 1997;112:1940–7.
Zaki M, Harrington L, McCuen R, Coy DH, Arimura A, Schubert ML. Somatostatin receptor subtype 2 mediates inhibition of gastrin and histamine secretion from human, dog, and rat antrum. Gastroenterology. 1996;111:919–24.
Beales I, Blaser MJ, Srinivasan S et al. Effect of Helicobacter pylori products and recombinant cytokines on gastrin release from cultured canine G cells. Gastroenterology. 1997;113:465–71.
Olbe L, Hamlet A, Dalenbäck J, Fändriks L. A mechanism by which Helicobacter pylori infection of the antrum contributes to the development of duodenal ulcer. Gastroenterology. 1996;110:1386–94.
Schubert ML, Makhlouf GM. Neural, hormonal, and paracrine regulation of gastrin and acid secretion. Yale J Biol Med. 1992;65:553–60.
Schmidt P, Poulsen SS, Hilsted L, Rasmussen TN, Holst JJ. Tachykinins mediate vagal inhibition of gastrin secretion in pigs. Gastroenterology. 1996;111:925–35.
El-Omar E, Penman I, Dorrian CA, Ardill JES, McColl KEL. Eradicating Helicobacter pylori infection lowers gastrin-mediated acid secretion by two-thirds in duodenal ulcer patients. Gut. 1993;34:1060–5.
Chittajallu RS, Howie CA, McColl KEL. Effect of Helicobacter pylori on parietal cell sensitivity to pentagastrin in duodenal ulcer patients. Scand J Gastroenterol. 1992;27:857–62.
Peterson WL, Barnett CC, Evans DJ Jr et al. Acid secretion and serum gastrin in normal subjects and patients with duodenal ulcer: the role of Helicobacter pylori. Am J Gastroenterol. 1993;88:2038–43.
Tarnasky PR, Kovacs TOG, Sytnik B, Walsh JH. Asymptomatic H. pylori infection impairs pH inhibition of gastrin and acid secretion during second hour of peptone meal stimulation. Dig Dis Sci. 1993;38:1681–7.
Hamlet A, Olbe L. The influence of Helicobacter pylori infection on post-prandial duodenal acid load and duodenal bulb pH in humans. Gastroenterology. 1996;111:391–400.
Kihl B, Olbe L. Inhibition of pentagastrin-stimulated gastric acid secretion by intraduodenal administration of graded doses of oleic acid in man. Scand J Gastroenterol. 1981;16:121–8.
Hamlet A, Lindholm C, Nilsson O, Olbe L. Aspirin-like Helicobacter pylori induced gastritis disinhibits acid secretion in humans; relation to cytokine expression. Scand J Gastroenterol. 1998 (In press).
Harris AW, Gummett PA, Walker MM, Misiewicz JJ, Baron JH. Relation between gastric acid output, Helicobacter pylori, and gastric metaplasia in the duodenal bulb. Gut. 1996;39:513–20.
Savarino V, Mela GS, Zentilin P et al. 24-hour gastric pH and extent of duodenal gastric metaplasia in Helicobacter pylori-positive patients. Gastroenterology. 1997;113:741–5.
Wyatt JI, Rathbone BJ, Sobala GM et al. Gastric epithelium in the duodenum: its association with Helicobacter pylori and inflammation. J Clin Pathol. 1990;43:981–6.
Hamlet A, Thoreson A-C, Nilsson O, Svennerholm A-M, Olbe L. Duodenal Helicobacter pylori infection differs between asymptomatic carriers and duodenal ulcer patients. (Submitted).
Noach LA, Rolf TM, Bosma NB et al. Gastric metaplasia and Helicobacter pylori infection. Gut. 1993;34:1510–14.
Atherton LP, Tham KT, Peek RM Jr, Cover TL, Blaser MJ. Density of Helicobacter pylori infection in vivo as assessed by quantitative culture and histology. J Infect Dis. 1996;174:552–6.
Censini S, Lange C, Xiang Z et al. cag, a pathogenicity island of Helicobacter pylori, encodes type 1-specific and disease-associated virulence factors. Proc Natl Acad Sci USA. 1996; 93:14648–53.
Bilski J, Konturek SJ. Role of nitric oxide in gastroduodenal alkaline secretion. J Physiol Pharmacol. 1994;45:541–53.
Takeuchi K, Ohuchi T, Miyake H, Okabe S. Stimulation by nitric oxide synthase inhibitors of gastric and duodenal HCO3 secretion in rats. J Pharmacol Exp Ther. 1993;266:1512–19.
Holm M, Johansson B, von Bothmer C, Jönson C, Pettersson A, Fändriks L. Acid-induced increase in duodenal mucosal alkaline secretion in the rat involves the L-arginine/NO pathway. Acta Physiol Scand. 1997;161:527–32.
Tepperman BL, Brown JF, Whittle BJR. Nitric oxide synthase induction and intestinal epithelial cell viability in rats. Am J Physiol. 1993;265:G214–18.
Takeuchi K, Matsumoto J, Ueshima K, Okabe S. Role of capsaicin-sensitive afferent neurons in alkaline secretory response to luminal acid in the rat duodenum. Gastroenterology. 1991;101:954–61.
Hamlet A, Jönson C, Fändriks L. The mediation of increased duodenal alkaline secretion in response to 10 mM HC1 in the anaesthetized rat. Support for the involvement of capsaicinsensitive nerve elements. Acta Physiol Scand. 1992;146:519–25.
Holm M, Johansson B, Pettersson A, Fändriks L. Acid-induced duodenal mucosal NO output parallels bicarbonate secretion in the anaesthetized pig. Acta Physiol Scand. (In press).
Isenberg JI, Selling JA, Hogan DL, Koss MA. Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer. N Engl J Med. 1987;316:374–9.
Hogan DL, Rapier RC, Dreilinger A et al. Duodenal bicarbonate secretion: eradication of Helicobacter pylori and duodenal structure and function in humans. Gastroenterology. 1996;110:705–16.
Fändriks L, von Bothmer C, Johansson B, Holm M, Bölin I, Pettersson A. Water extract of Helicobacter pylori inhibits duodenal mucosal alkaline secretion in anesthetized rats. Gastroenterology. 1997;113:1570–5.
Fändriks L, von Bothmer C, Lönroth H, Olbe L, Pettersson A. Presence of the NO-synthase inhibitor ADMA in H. pylori -infected antral mucosa. Abstract, DDW, New Orleans. 1998.
Karita M, Tummuru MKR, Wirth H-P, Blaser MJ. Effect of growth phase and acid shock on Helicobacter pylori cagA expression. Infect Immun. 1996;64:4501–7.
Wallace JL, Keenan CM, Granger DN. Gastric ulceration induced by non-steroidal drugs is a neutrophil-dependent process. Am J Physiol. 1990;259:G462–7.
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Olbe, L., Hamlet, A., Fändriks, L. (1998). Helicobacter pylori and gastroduodenal secretions. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4882-5_17
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DOI: https://doi.org/10.1007/978-94-011-4882-5_17
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