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Test-and-treat strategy in dyspepsia — the European perspective

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Helicobacter pylori

Abstract

Dyspepsia accounts for around 1–4% of all consultations in general practice according to surveys conducted in some European countries, but it is possible that many more adults suffer from this condition1–3.

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References

  1. Jones R, Lydeard S. Dyspepsia in the community: a follow-up study. Br J Clin Pract. 1992;46:95–97.

    PubMed  CAS  Google Scholar 

  2. Knill-Jones RP. Geographical differences in the prevalence of dyspepsia. Scand J Gastroenterol. 1991;26:17–24.

    Article  Google Scholar 

  3. Jones RH, Lydeard SE, Hobbs FRD et al. Dyspepsia in England and Scotland. Gut. 1999;31:401–405.

    Article  Google Scholar 

  4. Agreus L, Talley N. Challenges in managing dyspepsia in general practice. Br Med J. 1997;315:1284–1288.

    Article  CAS  Google Scholar 

  5. Talley NJ. Modern management of dyspepsia. Aust Fam Phys. 1996;25:47–52.

    CAS  Google Scholar 

  6. Black RJ, Bray F, Ferlay J, Parkin DM. Cancer incidence and mortality in the European Union: cancer registry data and estimates of national incidence for 1990. Eur J Cancer. 1997;33:1075–1107.

    Article  PubMed  CAS  Google Scholar 

  7. Tytgat G, Hingin APS, Malfertheiner P et al. Decision-making in dyspepsia: controversies in primary and secondary care. Eur J Gastroenterol Hepatol. 1999;11:223–230.

    Article  PubMed  CAS  Google Scholar 

  8. Sobala GM. Possible clinical uses of serology of Helicobacter pylori. In: Malfertheiner P, Ditschuneit H, editors. Helicobacter pylori, Gastritis and Peptic Ulcer. Berlin: Springer Verlag; 1990:147–153.

    Chapter  Google Scholar 

  9. European Helicobacter pylori Study Group. Current European concepts in the management of Helicobacter pylori infection. The Maastricht Consensus Report. Gut. 1997;41:8–13.

    Article  Google Scholar 

  10. Malfertheiner P. The Maastricht recommendations and their impact on general practice. Eur J Gastroenterol Hepatol. 1999;11,2:63–67.

    Article  Google Scholar 

  11. Sonnenberg A. Cost-benefit analysis of testing for Helicobacter pylori in dyspeptic subjects. Am J Gastroenterol. 1996;91:1773–1777.

    PubMed  CAS  Google Scholar 

  12. Blum AL, Talley NJ, O’Morain C et al. Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. Omeprazole plus clarithromycin and amoxicillin effect one year after treatment. (OCAY) Study Group. N Engl J Med. 1998;24,339,26:1875–1881.

    Article  Google Scholar 

  13. McColl K, Murray L, El-Omar E et al Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia. N Engl J Med. 1998;24,339,26:1869–1874.

    Article  Google Scholar 

  14. Talley NJ, Vakil N, Ballard ED, Fennerty MB. Absence of benefit of eradicating H. pylori in patients with nonulcer dyspepsia. N Engl J Med. 1999;7,341:1106–1111.

    Article  Google Scholar 

  15. Megraud F, Doermann HP. Clinical relevance of resistant strains: a review of current data. Gut. 1998;43:S61–5.

    Article  PubMed  Google Scholar 

  16. Silverstein MD, Petterson T, Talley NJ. Initial endoscopy or empirical therapy with or without testing for Helicobacter pylori for dyspepsia: a decision analysis. Gastroenterology. 1996;110:72–83.

    Article  PubMed  CAS  Google Scholar 

  17. Ofman JJ, Etchason J, Fullerton S et al. Management strategies for Helicobacter pylori-seropositive patients with dyspepsia: clinical and economic consequences. Ann Intern Med. 1997;126:280–291.

    Article  PubMed  CAS  Google Scholar 

  18. Lim AG, Martin RM, Monteleone M et al. Helicobacter pylori serology and the management of young dyspeptics: a UK survey of gastroenterologists and general practitioners with an interest in gastroenterology. Aliment Pharmacol Ther. 1997;11:299–303.

    Article  PubMed  CAS  Google Scholar 

  19. Logan RP. Urea breath tests in the management of Helicobacter pylori infection. Gut. 1998;41,1:S47–50.

    Article  Google Scholar 

  20. Leodolter A, Domingues-Munoz JE, von Arnim U, Kahl S, Peitz U, Malfertheiner P. Validity of a modified 13C-urea breath test for pre-and posttreatment diagnosis of Helicobacter pylori infection in the routine clinical setting. Am J Gastroenterol. 1999;94,8:2100–2104.

    Article  PubMed  CAS  Google Scholar 

  21. Thijs JC, van Zwet AA, Thijs WJ et al. Diagnostic tests for Helicobacter pylori: a prospective evaluation of their accuracy, without selecting a single test as the gold standard. Am J Gastroenterol. 1996;91,10:2125–2129.

    PubMed  CAS  Google Scholar 

  22. Cohen H, Rose S, Lewin DN et al. Accuracy of four commercially available serologic tests, including two office-based tests and a commercially available 13C urea breath test, for diagnosis of Helicobacter pylori. Helicobacter. 1999;4,1:49–53.

    Article  PubMed  CAS  Google Scholar 

  23. Vaira D, Malfertheiner P, Megraud F et al. Diagnosis of Helicobacter pylori infection with a new non-invasive antigen-based assay. Lancet. 1999;354:30–33.

    Article  PubMed  CAS  Google Scholar 

  24. Lassen AT, Pedersen FM, Byther P, Schaffalitzky de Muckadell OB. H. pylori ‘test and treat’ or prompt endoscopy for dyspeptic patients in primary care. A randomized controlled trial of two management strategies: one year follow up. Gastroenterology. 1998;114:G0803.

    Article  Google Scholar 

  25. Heaney A, Collins JSA, Watson RGP, McFarland RJ, Bamford KB, Tham TCK. A prospective randomised trial of a ‘test and treat’ policy versus endoscopy based management in young Helicobacter pylori positive patients with ulcer-like dyspepsia, referred to a hospital clinic. Gut. 1999;45:186–190.

    Article  PubMed  CAS  Google Scholar 

  26. Besherdas K, Oben JA, Beck ER, Vicary FR, Wong VS. What proportion of dyspeptic patients having H. pylori breath test subsequently undergo endoscopy? Gut. 2000;46,2:W78.

    Google Scholar 

  27. Moayyedi P, Zilles A, Clough A, Hemingbrough E, Chlamers DM, Axon ATR. The effectiveness of screening and treating Helicobacter pylori in the management of dyspepsia. Eur J Gastroenterol Hepatol. 1999;11:1245–1250.

    Article  PubMed  CAS  Google Scholar 

  28. Joosen EAM, Reininga JHA, Manders JMW, ten Ham JC, de Boer WA. Costs and benefits of a test-and-treat strategy in Helicobacter pylori-infected subjects: a prospective intervention study in general practice. Eur J Gastroenterol Hepatol. 2000;12:319–325.

    Article  PubMed  CAS  Google Scholar 

  29. Christie J, Shepherd NA, Codling BW, Valori RM. Gastric cancer below the age of 55: implications for screening patients with uncomplicated dyspepsia. Gut. 1997;41:513–517.

    Article  PubMed  CAS  Google Scholar 

  30. Gillen D, McColl KEL. Does concern about missing malignancy justify endoscopy in uncomplicated dyspepsia in patients aged less than 55? Am J Gastroenterol. 1999;94:75–79.

    Article  PubMed  CAS  Google Scholar 

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Malfertheiner, P. (2000). Test-and-treat strategy in dyspepsia — the European perspective. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3927-4_51

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  • DOI: https://doi.org/10.1007/978-94-011-3927-4_51

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5753-0

  • Online ISBN: 978-94-011-3927-4

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