Abstract
Arachidonic acid (AA) is converted into a number of biologically active metabolites, including prostaglandins, prostacyclin, thromboxane and leukotrienes via either the cyclo-oxygenase or lipoxygenase pathways (Pace-Asciak et al., 1983). Prostaglandin H synthase (PHS) is the initial enzyme in the cyclo-oxygenase pathway which commits AA to the formation of prostaglandins (Fig. 1.1). Two catalytic activities copurify with PHS, cyclo-oxygenase and peroxidase (Miyamoto et al., 1976). The cyclooxygenase catalyses the addition of two moles of oxygen to one mole of AA forming a cyclic endoperoxide hydroperoxide, prostaglandin (PG) G2. The peroxidase subsequently reduces the hydroperoxide to the corresponding alcohol, PGH2. PGH2 is then converted into a variety of other prostanoid metabolites, including thromboxanes, prostacyclin, and PGs E2 and F2α.
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© 1991 Springer Science+Business Media Dordrecht
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Eling, T.E., Curtis, J.F., Thompson, D.C., Van der Zee, J., Mason, R.P. (1991). Formation of aromatic amine free radicals by prostaglandin hydroperoxidase and peroxyl radicals: analysis by ESR and stable end products. In: Hlavica, P., Damani, L.A. (eds) N-Oxidation of Drugs. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3112-4_1
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DOI: https://doi.org/10.1007/978-94-011-3112-4_1
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