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The role of misoprostol in preventing NSAID-induced damage to the gastrointestinal tract

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Side-Effects of Anti-Inflammatory Drugs 3

Part of the book series: Inflammation and Drug Therapy Series ((IDTH,volume 5))

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Abstract

Soll [1] has recently reviewed the pathogenesis of gastric and duodenal ulcers caused by NSAIDs. These drugs, their prodrugs or enteric coated formulations damage the stomach and duodenum directly or indirectly (systemically). They share at least one common pharmacological property, namely, inhibition of cyclo-oxygenase, and it is by this mechanism that they reduce the ability of the mucosa to produce those prostaglandins which play a pivotal role in mucosal defence. The specific pathological pathways by which damage is induced remain speculative.

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Author notes

  1. Paul A. Nicholson

    Present address: SmithKline Beecham Phamaceuticals, PO Box 1510, King of Prussia, PA, 19406, USA

Authors and Affiliations

  1. G.D. Searle, 4901 Searle Parkway, Skokie, IL, 60077, USA

    Paul A. Nicholson

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  1. Paul A. Nicholson
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Editors and Affiliations

  1. Department of Biomedical Sciences and Pathology, McMaster University Faculty of Health Sciences, Hamilton, L8N 3Z5, Ontario, Canada

    K. D. Rainsford

  2. Istituto of Farmacologia, Università di Verona, Policlinico Borgo Roma, Verona, 37134, Italy

    G. P. Velo

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© 1992 Springer Science+Business Media Dordrecht

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Nicholson, P.A. (1992). The role of misoprostol in preventing NSAID-induced damage to the gastrointestinal tract. In: Rainsford, K.D., Velo, G.P. (eds) Side-Effects of Anti-Inflammatory Drugs 3. Inflammation and Drug Therapy Series, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2982-4_16

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  • DOI: https://doi.org/10.1007/978-94-011-2982-4_16

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5325-9

  • Online ISBN: 978-94-011-2982-4

  • eBook Packages: Springer Book Archive

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