Abstract
Immature and mature rat or human hepatocyte cultures and a human hepatoma cell line (Hep G2) were cultured in an arginine-free medium, supplemented or not with ornithine. In these different culture models, ornithine increases albumin and transferrin secretions. By using α-methyl ornithine, an inhibitor of ornithine decarboxylase, we demonstrate firstly that this effect of ornithine is mediated by polyamine production and secondly localized at a pretranslational level.
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Lescoat, G., Hubert, N., Brissot, P. (1990). Effect of ornithine on albumin and transferrin secretions in rat and human hepatocyte cultures. In: Lubec, G., Rosenthal, G.A. (eds) Amino Acids. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2262-7_109
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DOI: https://doi.org/10.1007/978-94-011-2262-7_109
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-72199-04-1
Online ISBN: 978-94-011-2262-7
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