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From Chromosome Number to Chromosome Map: the contribution of human cytogenetics to genome mapping

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Chromosomes Today

Abstract

Human chromosomes made virtually no contribution to the discipline of cytogenetics until the late 1950’s. This can be attributed, not to a lack of interest, but to inadequacy of the available material and technology. Mitoses could only be studied in histological sections of actively dividing tissues such as cancer material and samples of testis. Probably the first recorded description of human chromosomes was by Arnold in 1879 using mitotic cancer cells (Table 1). Hansemann in 1891 and Flemming in 1898 attempted to count the number of chromosomes in serial sections, obtaining crude estimates of approximately 24.

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    M. A. Ferguson-Smith

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Ferguson-Smith, M.A. (1993). From Chromosome Number to Chromosome Map: the contribution of human cytogenetics to genome mapping. In: Chromosomes Today. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1510-0_1

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  • DOI: https://doi.org/10.1007/978-94-011-1510-0_1

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