Abstract
We are investigating the use of parallel separation channels that utilize orthogonal separation techniques as a platform for a biosensor to accurately identify protein biotoxins. Two separation techniques were initially chosen for proof of concept demonstration—capillary zone electrophoresis (CZE) and capillary gel electrophoresis (CGE)—and have been implemented in our compact “µChemLab™” device. This device integrates automated high-voltage control of microchip-based separations with laser-induced fluorescence (LIF) detection and on-board data analysis. The effectiveness of this two-channel approach was evaluated using biotoxin-spiked aerosol samples.
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References
S.R. Wallenborg, C.G. Bailey and P.H. Paul, On-Chip Separation of Explosive Compounds—Divided Reservoirs to Improve Reproducibility and Minimize Buffer Depletion, Proc. of µTAS 2000, Springer Science+Business Media New York, Dordrecht, The Netherlands, pp. 355–358 (2000).
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© 2001 Springer Science+Business Media New York
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Fruetel, J. et al. (2001). Application of Microseparation Arrays to the Detection of Biotoxins in Aerosol Backgrounds. In: Ramsey, J.M., van den Berg, A. (eds) Micro Total Analysis Systems 2001. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-1015-3_224
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DOI: https://doi.org/10.1007/978-94-010-1015-3_224
Publisher Name: Springer, Dordrecht
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