Abstract
Phospholipids from tissue extracts have been used to differentiation between malignant and normal tissue and to identify tissues undergoing malignant transformations [1–10]. The investigations of 31 P spectra of sera of patients with hematological malignancies (acute leukemia, malignant lymphoma, multiple myeloma) and other cancers were clinical trials over the introduction of MRS (magnetic resonance spectroscopy) to monitor the therapy [11–14]. Moreover, changes of concentrations of phospholipids from extracts of sera and of mononuclear cells may explain the mechanism of their transport through cell membranes. Sphingomyelin (SM), as well as phosphatidylinositol (PI) and phosphatidylcholin (PC), is essential element of cellular signal transduction. Products of its degradation, i.e. ceramide and sphingosine are spontaneously transported through membranes and function as second messenger directed information to the cells [15–18]. Study aimed in comparison of 31P spectra acquired from extracts of phospholipid blast cells of patients with acute leukemia with these gained from lymphocyte extracts of healthy persons, with remarkable attention paid to sphingomyelin behavior.
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Kuliszkiewicz-Janus, M., Baczyński, B. (2002). Phospholipids’ Sera and Mononuclear Cells in Acute Leukemia, Malignant Lymphoma and Multiple Myeloma-Evaluation by 31P MRS in Vitro. In: Fraissard, J., Lapina, O. (eds) Magnetic Resonance in Colloid and Interface Science. NATO Science Series, vol 76. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0534-0_29
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DOI: https://doi.org/10.1007/978-94-010-0534-0_29
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