Abstract
The family of fibroblast growth factors (FGFs) plays important roles in various development and pathological states such as wound healing, tissue repair, and growth of some solid tumors [1], Because the abnormal expression of FGFs may contribute to several human pathologies such as arthritis, atherosclerosis, and tumor neovascularization [2], the development of FGF antagonists would be useful clinically. In our early work [3], several peptide ligands that bind to FGF were selected using a 15-mer phage-display peptide library. In this research, we expressed human FGF receptorl (FGFR1) on the surface of Sf9 insect cells. Peptide ligands binding to FGFR1 were screened using a phage-display 6-mer peptide library.
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Fan, H., Liu, Y., Zhou, H., Wang, L. W., Guo, L., Roeske, R.W. IUBMB Life 49 545 (2000).
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© 2001 Springer Science+Business Media Dordrecht
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Fan, H., Zhou, H., Li, W., Roeske, R.W., Guo, L. (2001). Selection of Antagonists of Fibroblast Growth Factor from a Phage-Display Peptide Library. In: Lebl, M., Houghten, R.A. (eds) Peptides: The Wave of the Future. American Peptide Symposia, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0464-0_433
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DOI: https://doi.org/10.1007/978-94-010-0464-0_433
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