Abstract
RNA-protein interaction plays important roles in nature [1]. In many cases, RNA-binding proteins target secondary structural domains such as hairpin loops, internal loops, and bulges of RNA [1]. For the sake of developing highly selective drugs against RNA, it is important to construct novel molecules that recognize highly structured RNA. For this purpose, we have attempted to design the peptides and proteins having the nucleobase moieties at the L-α-amino acid side chain (nucleobase amino acids; NBAs) [2], expecting that the recognition ability for RNA bases by NBAs can be utilized on peptide and protein conformation.
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Takahashi, T., Ueno, A., Mihara, H. (2001). Construction of RNA-Binding Proteins Having Nucleobase Amino Acids Based on HIV-1 Nucleocapsid Protein. In: Lebl, M., Houghten, R.A. (eds) Peptides: The Wave of the Future. American Peptide Symposia, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0464-0_240
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DOI: https://doi.org/10.1007/978-94-010-0464-0_240
Publisher Name: Springer, Dordrecht
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