Abstract
Cyclic peptides are excellent models for reverse turns, and it is well established that the cyclic hexapeptides contain two β-turns. In our previous studies, we reported the conformation of cyclo(Pro-Leu-Gly)2, and also the influence of the two Cα methyl groups of Aib on the formation of β-turns and overall conformation of cyclo-(Pro-Leu-Aib)2 [1,2]. The structure of cyclo(Pro-Leu-Gly)2 was comprised of two type I β-turns and the molecule had an overall C2 symmetry. The cyclo(Pro-Leu-Aib)2, however, exhibited an asymmetrical conformation containing two different types of β-turn (type II′ and type VI).
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References
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Osada, S. et al. (2001). Synthesis and Solution Structures of Cyclic Hexapeptides Cyclo(Pro-Leu-Xxx)2 . In: Lebl, M., Houghten, R.A. (eds) Peptides: The Wave of the Future. American Peptide Symposia, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0464-0_217
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DOI: https://doi.org/10.1007/978-94-010-0464-0_217
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