Abstract
DNA motions in taper-shape micro fluidic channels were observed by a fluorescence microscope. DNA flowed smoothly without stopping when only a hydro pressure, or only an electric field was applied. However, when both the hydro pressure and the electric force were applied at the same time in mutually reverse directions, DNA was trapped near the narrowest position in the channel. Trapped DNA was quickly released by removing one of the forces. The DNA trap was expected to be useful for on-chip DNA extraction and concentration at on-chip DNA pre-treatments.
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References
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J. Han, and H. G. Craighead, Separation of long DNA molecules in a microfabricated entropic trap array, Science, 288, pp. 1026–1029, (2000).
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© 2002 Springer Science+Business Media Dordrecht
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Takamura, Y., Hayama, T., Ueda, M., Baba, Y., Horiike, Y. (2002). DNA Trap-and-Release Element Employing Electric and Hydro Drag Force Fields for On-Chip Pre-Treatment. In: Baba, Y., Shoji, S., van den Berg, A. (eds) Micro Total Analysis Systems 2002. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0295-0_106
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DOI: https://doi.org/10.1007/978-94-010-0295-0_106
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-3952-9
Online ISBN: 978-94-010-0295-0
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