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Structure and Dynamics of Metal-Nucleic Acid Interactions

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Advances in Chemical Reaction Dynamics

Part of the book series: NATO ASI Series ((ASIC,volume 184))

Abstract

Fourier transform infrared spectra of complexes isolated from DNA and RNA interactions with Mg(II), Cu(II), Co(NH3)6 3+, Co(NH3)5C12+, cis- and trans-Pt(NH3)2 2+ were obtained and correlations between the spectral changes, coordination sites and conformational transitions are suggested. Spectroscopic evidence indicates that there is a direct metal interaction with the N7-site of the guanine base moiety and an indirect metal-phosphate binding through coordinated H2O or NH3 molecules for all the metal cation species employed, except for Co(NH3)6 3+. In the latter case there is an indirect metal-NH3….N7 and metal-NH3…O6 = C6, and an indirect metal-NH3…-0-P=0 interaction via the coordinated NH3 molecules.

The B to Z conformational transition was readily observed for the DNA molecule upon binding to the metal ions, whereas RNA conserves its A conformation in all the metal-RNA adducts. The marker bands for the B conformer (C2’-endo/anti) were observed at 825 (phosphodiester mode) and 690 cm-1 (guanine breathing mode). The marker bands were observed at 810 and 675 cmˉ1 for the A conformer (C3’-endo/anti). The B to Z conformational transition (C2’-endo/ anti to C3’-endo/syn) for the DNA molecule was accompanied with the bands at 810 cmˉ1 and 625–600 cmˉ1. The carbonyl band at 1701 in natural DNA shifts to lower frequencies upon a B to Z transition and the bands at 1485, 1371, 1285 and 1265 cm-1 also change considerably upon a B to Z transition.

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Authors and Affiliations

  1. Department of Chemistry, University de Montréal, C.P. 6128, Succ. A, Montréal, Québec, Canada, H3C 3J7

    T. Theophanides & H. A. Tajmir-Riahi

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  1. T. Theophanides
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  2. H. A. Tajmir-Riahi
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Editors and Affiliations

  1. Department of Chemistry, University of California, Irvine, California, USA

    Peter M. Rentzepis

  2. Energetics and Warheads Division, Armament Engineering Directorate, US Army Amament Research, Development and Engineering Center, Dover, New Jersey, USA

    Christos Capellos

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© 1986 D. Reidel Publishing Company

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Theophanides, T., Tajmir-Riahi, H.A. (1986). Structure and Dynamics of Metal-Nucleic Acid Interactions. In: Rentzepis, P.M., Capellos, C. (eds) Advances in Chemical Reaction Dynamics. NATO ASI Series, vol 184. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4734-4_34

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  • DOI: https://doi.org/10.1007/978-94-009-4734-4_34

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8604-2

  • Online ISBN: 978-94-009-4734-4

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