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Role of animal disease models in evaluating the efficacy of antimicrobial agents

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Comparative Veterinary Pharmacology, Toxicology and Theraphy
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Abstract

The advantages of the use of animal infectious disease models in determining the efficacy of antimicrobial agents are discussed. They are of particular interest in veterinary medicine as the antibiotic can be studied in the same species, where it will be used clinically. A good infectious disease model should fulfill several criteria. In our laboratory, we developed Streptococcus zooepidemicus disease models in beagle dogs and horses. The results are shortly discussed.

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References

  1. Garg, R., Powers, T. and Powers, J. (1978). Role of tissue cage models for studying the disposition of drugs in tissue. Abstract, Proc. Conf. of Res. Workers in Anim. Disease. November 1978.

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  2. Nara. P.L.. Krakowka, S., Powers, T.E. and Garg, R.C. (1983). Experimental Streptococcus equi infection in the horse: correlation with in vivo and in vitro immune responses. Am. J. Vet. Res. 44: 529–534.

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  3. Powers, T.E., Powers, J.D., Garg, R.C., Scialli, V.T. and Hajjans, G.H. (1980). Trimethoprim and sulfadiazine: experimental infection in beagles. Am. J. Vet. Res. 41: 1117–1122.

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  4. Powers, T.E., Garg, R.C., Gabel, A.A. and Kohn, C.W. (1981). Experimental Streptococcus zooepidemicus infection model in horses. Proc. Am. Coll. Vet. Intern. Med., 21.

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  5. Powers. T.E., Varma, K.J. and Powers, J.D. (1984). Selecting therapeutic concentrations: minimum inhibitory concentrations vs. sub- or supra-minimum inhibitory concentrations. J. Am. Vet. Med. Assoc. 185: 1062–1067.

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  6. Powers, J.D., Powers, T.E., Varma, K.J., Gabel, A.A. and Spurlock, S.L. (1984). A health index to clinically evaluate a Strep, disease model in the horse. J. Vet. Pharm. Ther. 7: 213–217.

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  7. Varma, K.J., Spurlock, S.L. and Powers, T.E. (1984). Standardization of an experimental disease model of Streptococcus zooepidemicus in equines. J. Vet. Pharm. Ther. 7: 183–188.

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© 1986 MTP Press Limited

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Powers, T.E., Varma, K.J., Powers, J.D. (1986). Role of animal disease models in evaluating the efficacy of antimicrobial agents. In: Van Miert, A.S.J.P.A.M., Bogaert, M.G., Debackere, M. (eds) Comparative Veterinary Pharmacology, Toxicology and Theraphy. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4153-3_37

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  • DOI: https://doi.org/10.1007/978-94-009-4153-3_37

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8343-0

  • Online ISBN: 978-94-009-4153-3

  • eBook Packages: Springer Book Archive

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