Abstract
A short review on the pharmacology of current antidiarrhoeal therapy is presented. Fluid replacement therapy and symptomatic therapy are useful in the treatment of diarrhoea of varying origin. The pharmacology of loperamide, alpha-2-agonists, anti-inflammatory drugs, chlorpromazine, trifluoperazine, parasympatholytics and serotonin-2-antagonists is discussed.
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References
Ahrens, F.A. and Zhu, B.L. (1982). Effects of epinephrine, clonidine, L-pheny1ephrine, and morphine on intestinal secretion mediated by Escherichia coli heat-stable enterotoxin in pig jejunum. Can. J. Physiol. Pharmacol. 60: 1680–1685.
Blaton, H., Niemegeers, C.J.E. and Marsboom, R. (1976). Preclinical animal studies of modern anti-diarrheals. Safety evaluation. In: Van Bever, W. and Lal, H. (eds). Modern Pharmacology-Toxicology. Vol. 7: Synthetic Antidiarrheal drugs, pp. 155–203. New York: Marcel Dekker Inc.
Burks, T.F. (1973). Mediation by 5-hydroxytryptamine of morphine stimulant actions in dog intestine. J. Pharmacol. Exp. Ther. 185: 530–539.
Chang, E.B., Field, M. and Miller, R.J. (1983). Enterocyte alpha 2-adrenergic receptors: yohimbine and p-aminoc1onidine binding relative to ion transport. Am. J. Physiol. 244: 676–682.
Dobbins, J.W. and Binder, H.J. (1981). Pathophysiology of diarrhoea: alterations in fluid and electrolyte transport. Clin. Gastroent. 10: 605–625.
Doherty, N.S. and Hancock, A.A. (1983). Role of alpha-2 adrenergic receptors in the control of diarrhea and intestinal motility. J. Pharmacol. Exp. Ther. 225: 269–274.
Durbin, T., Rosenthal, L., McArthur, K., Anderson, D. and Dharmsathaphorn, K. (1982). Clonidine and lidamidine (WHR-1142) stimulate sodium and chloride absorption in the rabbit intestine. Gastroenterology 82: 1352–1358.
Farack, U.M., Kautz, U. and Loeschke, K. (1981). Loperamide reduces the intestinal secretion but not the mucosal cAMP accumulation induced by cholera toxin. Naunyn-Schmiedeberg’s Arch. Pharmacol. 317: 178–179.
Glauischnig, E., Pichler, P., Fehr, P. and Dourakas, E. (1974). Uber die Wirkung von Spasmentral bei Durchfal1erkrankungen des Rindes. Dtsch. Tierarztl. Wochenschr. 81: 549–604.
Gordon, S.J., Kinsey, M.D., Magan, S.J., Joseph, R.E. and Kowlessar, O.D. (1978). Effect of bile acid induced secretion in the rat caecum. Gastroenterology 74 (5) part 2: 1040.
Gullikson, G.W., Dajani, E.Z. and Bianchi, R.G. (1981). Inhibition of intestinal secretion in the dog: a new approach for the management of diarrheal states. J. Pharmacol. Exp. Ther. 219: 591–597.
Gullikson, G.W., Jasty, V. and Dajani, E.Z. (1981). Effect of lidamidine on deoxycholate-induced histological and permeability changes in canine jejunum. The Pharmacologist 23: 122.
Hardcastle, J., Hardcastle, P.T., Read, N.W. and Redfern, J.S. (1981). The action of loperamide in inhibiting prostag1andin-induced intestinal secretion in the rat. Br. J. Pharmacol. 74: 563–569.
Hughes. Higgs, N.B. and Turnberg, L.A. (1983). Loperamide has antisecretory activity in vivo in human jejunum. Gut 24: A495.
Huidobro-Toro. J.P. and Leong Way. E. (1981). Contractile effect of morphine and related opioid alkaloids, beta-endorphin and methionine enkephaline on the isolated colon from long evans rats. Br. J. Pharmacol. 74: 681–694.
Ilundain, A. and Naftalin, R.J. (1981). Opiates increase chloride permeability of the serosal border of the rabbit ileum. J. Physiol. 316: 56–57.
Jones. E.W., Corley, L., Hamm. D. and Bush, L. (1977). Calf diarrhea: a brief resumé with observations on treatment and prevention. Bovine Pract. 12: 48–54.
Karim, S.M.M. and Adaikan, P.G. (1977). The effect of loperamide on prostaglandin induced diarrhoea in rat and man. Prostaglandins 13: 321–331.
Kisloff, B. and Moore. E.W. (1976). Effect of serotonin and water and electrolyte transport in the in vivo rabbit small intestine. Gastroenterology 71: 1033–1038.
Kromer. U.. Scheiblhuber, E. and Illes, P. (1980). Functional antagonism by calcium of an intrinsic opioid mechanism in the guinea-pig isolated ileum. Neuropharmacology 19: 839–843.
Kvietys, P.P., Wilborn. W.H.. Granger. D.N. and Cuccias. H. (1981). Effect of atropine on bile-oleic acid-induced alterations in dog jejunal hemodynamics, oxygenation and net transmucosal uater movement. Gastroenterology 80: 31–38.
Lange. A.. Secher. N.J. and Amery, U. (1977). PGE2 induced secretion of fluid and electrolytes was reversed to absorption. Acta Med. Scand. 202: 449–454.
Lecce. J.G.. Clare. D.P.. Balsbaugh, R.K. and Collier. D.N. (1983). Effect of dietary regimen on rotavirus- Escherichia coli weanling diarrhea of piglets. J. Clin. Microbiol. 17: 689–695.
Limbird. L.E. (1983). Alpha-2-adrenergic systems: models for exploring hormonal inhibition of adenylate cyclase. TIPS 4: 135–137.
Lonroth. I., Andren, B.. Lange. S. et al. (1979). Chlorpromazine reverses diarrhea in piglets caused by enterotoxic Escherichia coli. Infect. Immun. 24: 900–905.
Merritt. J.E., Brown. B.L. and Tomlinson, S. (1982). Loperamide and calmodulin. Lancet i: 283–284.
Mir, G.N.. Alioto, R.L.. Sperow, J.W. et al. (1978). In vivo antimotility and antidiarrheal activity of lidamidine hydrochloride (WHR-1142A), a novel anti-diarrheal agent. Arzneim. Forsch. 28: 1448–1454.
Naftalin, R.J. (1982). Control of small intestinal absorption and secretion by modulation of the mucosal and serosal border chloride permeabi1ity. In: Case, R.M.. Garner, A., Turnberg, L.A. and Young, J.A. (eds). Electrolytes and Water Transport Across the Gastrointestinal Epithelia, pp. 277–285. New York: Raven Press.
Niemegeers, C.J.E., McGuire. J.L., Heykants, J.J.P. and Janssen, P.A.J. (1979). Experimental dissociation between opiate-like and antidiarrheal drugs. J. Pharmacol. Exp. Ther. 210: 327–333.
Ooms, L. (1983). Alterations in intestinal fluid movement. Scand. J. Gastroenterol. 18 (SUPPI. 84): 65–77.
Ooms, L. and Degryse, A. (1982). Antiserotonergic compounds in secretory diarrhea. Funds for Sci. Med. Res. 496–502.
Ooms, L.A.A., Degryse, A.-D. and Janssen, P.A.J. (1984). Mechanisms of action of loperamide. Scand. J. Gastroenterol. 19 (Suppl. 96): 145–155.
Ruckebusch. Y., Buéno, L. and Fioramonti, J. (1981). Workshop: stress and serotonin in animals and man. Janssen Pharmaceutica. Beerse, Belgium.
Sandhu, B. (1981). Loperamide and cholera secretion. Clinical Res. Rev. 1 (Suppl. 1): 155–159.
Schreiner, J., Nell, G. and Loeschke, K. (1980). Effect of diphenolic laxatives on Na+-K+-activated ATPase and cyclic nucleotide content of rat colon mucosa in vivo. Naunyn-Schmiedeberg’s Arch. Pharmacol. 313: 249–255.
Smith, P.L., Blumberg, J.B., Stoff, J.S. and Field, M. (1981). Antisecretory effects of indomethacin on rabbit ileal mucosa in vitro. Gastroenterol. 80: 356–365.
Symoens, J., Geerts, H. and Van Gestel, J. (1974). Benzetimide in the treatment of diarrhoea in newborn calves and adult cattle. Vet. Rec. 94: 180–183.
Thomas, D.D. and Knoop, F.C. (1982). The effect of calcium and prostaglandin inhibitors on the intestinal fluid response to heat-stable enterotoxin of Escherichia coli. J. Infect. Dis. 145: 141–147.
Verhaeren, E.H.C., Dreessen, M.J. and Lemli, J.A. (1981). Influence of 1,8-dihydroxyanthraquinone and loperamide on the paracellular permeability across colonic mucosa. J. Pharm. Pharmacol. 33: 526–528.
WHO Diarrheal Disease Control Programme (1979). WHO Wkly Epidem. Rec. 54: 121–123.
Wise, C.M., Knight, A.P., Lucas, M.J., Morris, C.J., Ellis. R.P. and Phillips, R.W. (1983). Effects of salicylates on intestinal secretion in calves given (intestinal loops) Escherichia coli heat-stable enterotoxin. Am. J. Vet. Res. 44: 2221–2225.
Yagasaki, O., Suzuki, H. and Sohji, Y. (1978). Effects of loperamide on acetylcholine and prostaglandin release from isolated guinea pig ileum. Jap. J. Pharmacol. 28: 873–882.
Zavecz, J.H., Jackson, T.E., Limp, G.L. and Yellin, T.O. (1982). Relationship between anti-diarrheal activity and binding to calmodulin. Eur. J. Pharmacol. 78: 376–377.
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Ooms, L.A.A., Degryse, AD. (1986). Antidiarrhoeal therapy. In: Van Miert, A.S.J.P.A.M., Bogaert, M.G., Debackere, M. (eds) Comparative Veterinary Pharmacology, Toxicology and Theraphy. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4153-3_32
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DOI: https://doi.org/10.1007/978-94-009-4153-3_32
Publisher Name: Springer, Dordrecht
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