Disposition and metabolism of 14C-mebendazole in sheep and poultry

Bénard, P.; Burgat-Sacaze, V.; Massat, F.; Rico, A. G.

doi:10.1007/978-94-009-4153-3_29

P. Bénard,
V. Burgat-Sacaze,
F. Massat &
…
A. G. Rico

356 Accesses
2 Citations

Abstract

In sheep, guinea-fowl chicks and laying hen-pheasants, dosed orally with ¹⁴C-mebendazo1e, radioactivity was distributed in several compartments. The terminal half-life was between 189.6 and 304.8 h in sheep and between 132.5 and 150.6 h in birds. Radioactivity was detected in all the tissues examined and rather high residual concentrations were present in the melanin-containing tissues and in the liver, 15 days (guinea-foul chicks and hen-pheasants) and 30 days (sheep) after administration. In sheep liver a concentration of 1.23 μg unchanged mebendazole per g of wet tissue was measured 30 days after dosing.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Chapter: USD 29.95; Price excludes VAT (USA)

eBook: USD 39.99; Price excludes VAT (USA)

Softcover Book: USD 54.99; Price excludes VAT (USA)

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

References

Bénard, P., Rico, A.G., Braun, J.P., Burgat, V., Bonnaud, B. and Cousse, H. (1981). Picafibrate. Note II: Absorption, distribution et élimination chez le rat après marquage au carbone-14. Boll. Chim. Farm. 120: 114–123.
PubMed Google Scholar
Bénard. P., Burgat, V., Mlassat. F. and Rico, A.Gc (1984). Metabolism of C-14-mebendazo1e in sheep. 9th European Congress on Drug Metabolism Workshop, Pont â Mousson, Abstract, P4.
Google Scholar
Burqat-Sacaze, V. and Rico, A.G. (1984). Bioactivation and bound residues. Food Additives and Contaminants 2: 121–129.
Google Scholar
Ullberg, S. (1954). Studies on the distribution and fate of S-35-1abel1ed benzyl penici11in in the body. Acta Radiol.. Suppl. 118: 1–110.
CAS Google Scholar

Download references

Authors

P. Bénard
View author publications
You can also search for this author in PubMed Google Scholar
V. Burgat-Sacaze
View author publications
You can also search for this author in PubMed Google Scholar
F. Massat
View author publications
You can also search for this author in PubMed Google Scholar
A. G. Rico
View author publications
You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

Institute of Veterinary Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, University of Utrecht, P. O. Box 80. 176, 3508 TD, Utrecht, The Netherlands
A. S. J. P. A. M. Van Miert
J. F. and C. Heymans Institute of Pharmacology, University of Ghent, Medical School, De Pintelaan 185, B-9000, Ghent, Belgium
M. G. Bogaert
Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ghent, Casinoplein 24, B-9000, Ghent, Belgium
M. Debackere

Rights and permissions

Reprints and permissions

Copyright information

About this chapter

Cite this chapter

Bénard, P., Burgat-Sacaze, V., Massat, F., Rico, A.G. (1986). Disposition and metabolism of ¹⁴C-mebendazole in sheep and poultry. In: Van Miert, A.S.J.P.A.M., Bogaert, M.G., Debackere, M. (eds) Comparative Veterinary Pharmacology, Toxicology and Theraphy. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4153-3_29

Download citation

DOI: https://doi.org/10.1007/978-94-009-4153-3_29
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8343-0
Online ISBN: 978-94-009-4153-3
eBook Packages: Springer Book Archive

Publish with us

Policies and ethics