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The potential of biological response modifiers in the treatment of malignancies in animals and man

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Comparative Veterinary Pharmacology, Toxicology and Theraphy

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Abstract

Bacillus Calmette-Guérin (BCG) was able to induce regression of established tumours in an experimental guinea-pig tumour system, and in two spontaneously occurring tumours of farm animals. In the guinea-pig tumour system a tumour line-specific immunity remained, indicating that antigen presentation occurred during BCG-induced tumour regression. In bovine ocular squamous cell carcinoma (BOSCC) and sarcoid tumours of the skin in the horse a substantial number of animals shoued tumour regression (approximately 70%). Local BCG immunotherapy seems promising especially for equine sarcoid tumours of the skin. These findings are discussed in relation to the results obtained with BCG immunotherapy in clinical trials in man.

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Authors
  1. E. J. Ruitenberg
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  2. W. H. De Jong
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  3. P. A. Steerenberg
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  4. W. R. Klein
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  5. V. P. M. G. Rutten
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Editor information

Editors and Affiliations

  1. Institute of Veterinary Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, University of Utrecht, P. O. Box 80. 176, 3508 TD, Utrecht, The Netherlands

    A. S. J. P. A. M. Van Miert

  2. J. F. and C. Heymans Institute of Pharmacology, University of Ghent, Medical School, De Pintelaan 185, B-9000, Ghent, Belgium

    M. G. Bogaert

  3. Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ghent, Casinoplein 24, B-9000, Ghent, Belgium

    M. Debackere

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© 1986 MTP Press Limited

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Ruitenberg, E.J., De Jong, W.H., Steerenberg, P.A., Klein, W.R., Rutten, V.P.M.G. (1986). The potential of biological response modifiers in the treatment of malignancies in animals and man. In: Van Miert, A.S.J.P.A.M., Bogaert, M.G., Debackere, M. (eds) Comparative Veterinary Pharmacology, Toxicology and Theraphy. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4153-3_24

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  • DOI: https://doi.org/10.1007/978-94-009-4153-3_24

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8343-0

  • Online ISBN: 978-94-009-4153-3

  • eBook Packages: Springer Book Archive

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