Abstract
When human fibroblast cells are induced to produce IFN-β by treatment with poly (I).poly(C) in the presence of cycloheximide, synthesis of a protein of 26kDa (1),earlier described as IFN-β2 by Weissenbach et al. (2)is stimulated. Peripheral blood lymphocytes (3) and epithelial cells (4) also express the 26kDa protein mRNA when appropriately induced. Recently, the nucleotide sequence of the entire coding region of the 26kDa protein mRNA has been described. Despite extensive searches, no statistically significant sequence homology with any known interferon species was found (5).
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© 1987 Martinus Nijhoff Publishers, Dordrecht
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Defilippi, P., Poupart, P., Haegeman, G., Tavernier, J., Fiers, W., Content, J. (1987). Induction of 26kDa Protein mRNA in Human Cells Treated with Recombinant Human Tumour Necrosis Factor (rTNF). In: Cantell, K., Schellekens, H. (eds) The Biology of the Interferon System 1986. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3543-3_30
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DOI: https://doi.org/10.1007/978-94-009-3543-3_30
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