Abstract
The solubilizing capacity of some highly water soluble ß-cyclodextrin (ßCD) derivatives were compared on several drugs. The methylated ßCD derivatives — except the 2,3,6-tri-O-methyl- ßCD (TRIMEB) — were found to be potent solubilizers for all studied guest molecules. The solubilizing effect of 2-hydroxypropyl- ßCD (HPBCD) strongly depends on both the properties of guest and the number of substituents on the ßCD ring. The 3-monosuccinyl- heptakis-2,6,-dimethyl derivative of ßCD (SUMEB) was found to be the most efficient solubilizing agent for the free base form of some drugs. The crystallizable derivatives are not hygroscopic, while the randomly substituted ones are strongly hygroscopic.
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© 1988 Kluwer Academic Publishers
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Szemán, J., Szente, L., Szabó, T., Szejtli, J. (1988). Highly Soluble ß-Cyclqdextrin Derivatives, a Comparative Study. In: Huber, O., Szejtli, J. (eds) Proceedings of the Fourth International Symposium on Cyclodextrins. Advances in Inclusion Science, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2637-0_57
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DOI: https://doi.org/10.1007/978-94-009-2637-0_57
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-7690-6
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