Abstract
The most obvious hazard from the microbial contamination of medicines is infection, but more subtle degradative changes can occur which may also be clinically significant. These changes can include the biodegradation of formulation excipients leading to an alteration in the physicochemical characteristics of a product, or metabolism of the drug itself. Such drug transformations, while infrequently found in contaminated pharmaceutical products, are known to occur in the laboratory and after drug administration in vivo through the action of commensal organisms.
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References
Anon. (1983). Pharmaceutical Journal, 230, 300.
Baird, R.M. This volume, pp. 152–6.
Beveridge, E.G. (1975). In Microbial Aspects of the Deterioration of Materials, SAB Technical Series No. 9, ed. D.W. Lovelock & R.J. Gilbert. Academic Press, London, pp. 213–35.
Beveridge, E.G. (1983). In Pharmaceutical Microbiology, 3rd edition, ed. W.B. Hugo & A.D. Russell, Blackwell Scientific Publications, Oxford, pp. 334–53.
Cox, P.H. & Sewell, B.A. (1968). Journal of the Society for Cosmetic Chemists, 19, 461–7.
Denyer, S.P., Guy, R.H., Hadgraft, J. & Hugo, W.B. (1985). International Journal of Pharmaceutics, 26, 89–97.
Fernandez, G.S. & Genis, M.V. (1979). Pharmaceutica Acta Helvetiae, 54, 78–81.
Goldman, P.(1982). In Microbial Transformation of Bioactive Compounds, Volume II, ed. J.P. Rosazza. CRC Press Inc. Florida, pp. 43–65.
Grant, D.J.W. (1973). Journal of Applied Bacteriology, 36, 47–59.
Kedzia, W., Lewan, J. & Wismienski, T. (1961). Journal of Pharmacy and Pharmacology, 13, 614–19.
Midvedt, T. & Linstedt, G. (1910). Acta Pathologica et Microbiologica Scandinavica, Section B, 78, 488–94.
Noble, W.C. (1981). Microbiology of Human Skin, 2nd edn, Lloyd-Luke, London.
Parker, M.S. (1984). International Biodeterioration, 20, 151–6.
Parker, M.S. & Barnes, M. (1967). Soap, Perfumery and Cosmetics, December Issue, 1–4.
Renwick, A.G. (1986). In Microbial Metabolism in the Digestive Tract, ed. M.J. Hill. CRC Press Inc., Florida, pp. 135–53.
Robinson, E.P. (1971). Journal of Pharmaceutical Sciences, 60, 604–5.
Smart, R. & Spooner, D.F. (1972). Journal of the Society for Cosmetic Chemists, 23, 721–37.
Spooner, D.F. (1987). In Microbial Quality Assurance in Non-sterile Pharmaceuticals, Cosmetics and Toiletries, ed. S.F. Bloomfleld. Ellis Horwood Ltd, Chichester (in press).
Westwood, N. & Pin-Lim, B. (1971). Pharmaceutical Journal, 207, 99–102.
Wills, B.A. (1958). Journal of Pharmacy and Pharmacology, 10, 302–5.
Wogan, G.N. (1975). Annual Review of Pharmacology, 15, 437–51.
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© 1988 Elsevier Science Publishers Ltd
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Denyer, S.P. (1988). Clinical Consequences of Microbial Action on Medicines. In: Houghton, D.R., Smith, R.N., Eggins, H.O.W. (eds) Biodeterioration 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1363-9_19
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DOI: https://doi.org/10.1007/978-94-009-1363-9_19
Publisher Name: Springer, Dordrecht
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