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Pantothenic Acid (Vitamin B5), Coenzyme A and Related Compounds

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Book cover Biotechnology of Vitamins, Pigments and Growth Factors

Part of the book series: Elsevier Applied Biotechnology Series ((APBISE))

Abstract

Pantothenic acid (R- or d-(+)-N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine; for chemical formula, see Table 1) was first isolated in the 1930s from liver and found to be an essential growth factor for yeasts (Williams and co-workers, 1943). During this same period, it was also identified independently with the chick anti-dermatitis factor, the filtrate factor, the chick anti-pellagra factor and an essential growth factor for lactic acid bacteria. Later these activities were shown to be identical with pantothenic acid. Since the factor could be obtained from a variety of plants and animal tissues, it was designated pantothenic acid, meaning “from everywhere” by Williams. The compound is also referred to as vitamin B5. It was independently synthesized by two groups in 1940.

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Authors and Affiliations

  1. Department of Agricultural Chemistry, Kyoto University, Kyoto, 606, Japan

    S. Shimizu & H. Yamada

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  1. S. Shimizu
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  2. H. Yamada
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  1. Laboratory of General and Industrial Microbiology, State University of Ghent, Belgium

    Erick J. Vandamme

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Shimizu, S., Yamada, H. (1989). Pantothenic Acid (Vitamin B5), Coenzyme A and Related Compounds. In: Vandamme, E.J. (eds) Biotechnology of Vitamins, Pigments and Growth Factors. Elsevier Applied Biotechnology Series. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1111-6_12

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  • DOI: https://doi.org/10.1007/978-94-009-1111-6_12

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