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Anaesthesia and Major Surgery in Patients with Renal Failure

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Replacement of Renal Function by Dialysis
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Abstract

In the last few years there has been, thanks to advances in nephrology, a complete change in the fields of anaesthesia and surgery in relation to patients with renal failure. It is, for example, no longer the rule that they come to the operating room for renal transplantation showing major patho-physiological features of uraemia, such, for example, as gross metabolic acidosis, a bleeding tendency and a high plasma potassium. Now their blood pressure is generally well-controlled, they are not suffering from gross overhydration and their general condition is frequently good. As nephrology has advanced, so has anaesthesia become simpler. A simple summary of the practical problems which face the surgeon and the anaesthetist are given in Table 1.

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References

  1. Bastron RD, Perkins FM, Kaloyanides GI: In vitro inhibition of p-aminohippurate transport by halogenated anesthetics. J Pharmacol Exp Ther 200: 75, 1977

    PubMed  CAS  Google Scholar 

  2. Jacobsen E, Christiansen AH, Lunding M: The role of the anaesthetist in the management of acute renal failure. Br J Anaesth 40: 442, 1968

    Article  PubMed  CAS  Google Scholar 

  3. Mazze RI, Schwartz FD, Slocum HC, Barry MG: Renal function during anesthesia and surgery; the effects of halothane anesthesia. Anesthesiology 24: 279, 1963

    Article  Google Scholar 

  4. Deutsch S, Goldberg M, Stephen GW, Wu WH: Effects of halothane anesthesia on renal function in normal man. Anesthesiology 27: 793, 1966

    Article  PubMed  CAS  Google Scholar 

  5. Deutsch S, Pierce EC Jr, Vandam LD: Cyclopropane effects on renal function in normal man. Anesthesiology 28: 547, 1967

    PubMed  CAS  Google Scholar 

  6. Deutsch S, Bastron RD, Pierce EC Jr, Vandam LD: The effect of anaesthesia with thiopentone, nitrous oxide, narcotics and neuromuscular blocking drugs on renal function in normal man. Br J Anaesth 41: 807, 1969

    Article  PubMed  CAS  Google Scholar 

  7. Mazze RI, Cousins MJ, Barr GA: Renal effects and metabolism of isoflurane in man. Anesthesiology 40: 536, 1974

    Article  PubMed  CAS  Google Scholar 

  8. Cousins MJ, Greenstein LR, Hitt BA, Mazze RI: Metabolism and renal effects of enflurane in man. Anesthesiology 44: 44, 1976

    Article  PubMed  CAS  Google Scholar 

  9. Vatner SF, Smith NT: Effects of halothane on left ventricular function and distribution of regional blood flow in dogs and primates. Circ Res 34: 155, 1974

    PubMed  CAS  Google Scholar 

  10. Bastron RD, Pyne JL, Inagaki M: Halothane induced renal vasodilation. Anesthesiology 50: 125, 1979

    Article  Google Scholar 

  11. Bastron RD, Perkins RM, Pyne JL: Autoregulation of renal blood flow during halothane anesthesia. Anesthesiology 46: 142, 1977

    Article  PubMed  CAS  Google Scholar 

  12. Miller RL, Forsyth RR, Melmon KL: Morphine induced redistribution of cardiac output in the unanesthetized monkey. Pharmacology 7: 138, 1972

    Article  PubMed  CAS  Google Scholar 

  13. Priano LL, Vatner SF: Morphine effects on cardiac output and regional blood flow distribution in conscious dogs. Anesthesiology 55: 236, 1981

    Article  PubMed  CAS  Google Scholar 

  14. Don HF, Dieppa RA, Taylor P: Narcotic analgesics in anuric patients. Anesthesiology 42: 745, 1975

    Article  PubMed  CAS  Google Scholar 

  15. Gorman HM, Craythorne NWB: The effects of a new neurolept-analgesic agent (Innovar) on renal function in man. Acta Anaesth Scand Suppl 24: 111, 1966

    Google Scholar 

  16. Miles BE, de Wardener HE, Churchill-Davidson HC, Wylie WD: The effect of the renal circulation of pentamethonium bromide during anaesthesia. Clin Sci 11: 73, 1952

    PubMed  CAS  Google Scholar 

  17. Wang HH, Lui LMP, Katz RL: A comparison of the cardiovascular effects of sodium nitroprusside and trimethaphan. Anesthesiology 46: 40, 1977

    Article  PubMed  CAS  Google Scholar 

  18. Engelman RM, Guy HH, Smith SJ, Boyd AD, Narbay RD, Turndorf H: The effect of hypotensive anesthesia on renal haemodynamics. J Surg Res 18: 293, 1975

    Article  PubMed  CAS  Google Scholar 

  19. Crandell WB, Pappas SG, Macdonald A: Nephrotoxicity associated with methoxyflurane anesthesia. Anesthesiology 27:591, 1966

    Article  PubMed  CAS  Google Scholar 

  20. Panner BJ, Freeman RB, Rath-Mayo I A: Toxicity following methoxyflurane anesthesia. Clinical and pathological observations in two fatal cases. JAMA 214: 86, 1970

    Article  PubMed  CAS  Google Scholar 

  21. Hollenberg NK, McDonald FD, Cotran R: Irreversible acute oliguric renal failure; a complication of methoxyflurane anesthesia. N Eng J Med 286: 877, 1972

    Article  CAS  Google Scholar 

  22. Frascino JA, Venamee P, Rosen PP: Renal oxalosis and azotaemia after methoxyflurane anesthesia. N Engl J Med 283: 676, 1970

    Article  PubMed  CAS  Google Scholar 

  23. Mazze RI, Cousins MJ: Methoxyflurane nephrotoxicity — a study of dose-response in man. JAMA 225: 1611, 1973

    Article  PubMed  Google Scholar 

  24. Barr GA, Mazze RI, Cousins MJ, Kose KJ: An animal model for combined methoxyflurane and gentamicin nephrotoxicity. Br J Anaesth 45: 306, 1973

    Article  PubMed  CAS  Google Scholar 

  25. Kuzucu EY: Methoxyflurane, tetracycline, and renal failure. JAMA 211: 1162, 1970

    Article  PubMed  CAS  Google Scholar 

  26. Cousins MJ, Mazze RI: Anaesthesia, surgery and renal function, immediate and delayed effects. Anaesth Intensive Care 1: 355, 1973

    PubMed  CAS  Google Scholar 

  27. Harnett MN, Lane W, Bennett WM: Non-oliguric renal failure and enflurane. Ann Intern Med 81: 560, 1974

    Google Scholar 

  28. Lockning R, Mazze RI: Possible nephrotoxicity from enflurane in patient with severe renal disease. Anesthesiology 40: 203, 1974

    Article  Google Scholar 

  29. Eichorn JH, Hedley-Whyte J, Steinman TI, Kaufmann JM, Laasberg LH: Renal failure following enflurane anesthesia. Anesthesiology 45: 557, 1976

    Article  Google Scholar 

  30. Mazze RI, Cousins MJ, Barr GA: Renal effects and metabolism of isoflurane in man. Anesthesiology 40: 536, 1974

    Article  PubMed  CAS  Google Scholar 

  31. Mazze RI, Sievenpiper TS, Stevenson J: Renal effects of enflurane and halothane in patients with abnormal renal function. Anesthesiology 60: 161, 1984

    Article  PubMed  CAS  Google Scholar 

  32. Priebe HJ, Hedley-White J: Respiratory support and renal function in International Anesthesiology Clinics, 22, No 1, edited by Priebe HJ, Boston, Little Brown and Co, 1984

    Google Scholar 

  33. Moore ES, Galvez MB, Paton JB, Fisher DE, Behrman RE: Effects of positive pressure ventilation on intrarenal blood flow in infant primates. Prediatr Res 8: 792, 1974

    CAS  Google Scholar 

  34. Hemmer M, Viquerat CE, Suter PM, Vallotton MB: Urinary antidiuretic hormone excretion during mechanical ventilation and weaning in man. Anesthesiology 52: 395, 1980

    Article  PubMed  CAS  Google Scholar 

  35. Gett PM, Jones ES, Shepherd GF: Pulmonary oedema associated with sodium retention during ventilator treatment. Br J Anaesth 43: 460, 1971

    Article  PubMed  CAS  Google Scholar 

  36. Tarak TK, Chaudhury RR: The mechanism of positive pressure respiration induced antidiuresis in rats. Clin Sci 28: 407, 1965

    PubMed  CAS  Google Scholar 

  37. Sladen A, Laver MD, Pontoppidan H: Pulmonary complications and water retention in prolonged mechanical ventilation. N Engl J Med 279: 448, 1968

    Article  PubMed  CAS  Google Scholar 

  38. Khambatta HJ, Baratz RA: IPPB, plasma ADH, and urine flow in conscious man. J Appl Physiol 33: 362, 1972

    PubMed  CAS  Google Scholar 

  39. Verma YS, Gupta KK, Mehta S, Chaudhury RR: A study of plasma antidiuretic activity before and during intermittent positive pressure respiration in human subjects. Indian J Med Res 56: 73, 1968

    PubMed  CAS  Google Scholar 

  40. Baratz RA, Philbin DM, Patterson RW: Urinary output and plasma levels of antidiuretic hormone during intermittent positive-pressure breathing in the dog. Anesthesiology 32: 17, 1970

    Article  PubMed  CAS  Google Scholar 

  41. Fewell JE, Bond GC: Renal denervation eliminates the renal response to continuous positive pressure ventilation. Proc Soc Exp Biol Med 161: 574, 1979

    PubMed  CAS  Google Scholar 

  42. Bromage PR, Gertel M: Brachial plexus anesthesia in chronic renal failure. Anesthesiology 36: 488, 1972

    Article  PubMed  CAS  Google Scholar 

  43. Orko R, Pitkanen M, Rosenberg PH: Subarachnoid anaesthesia with 0.75% bupivacaine in patients with chronic renal failure. Br J Anaesth 58: 605, 1986

    Article  PubMed  CAS  Google Scholar 

  44. Rooke NT, Milne B: Acute pulmonary edema after regional anesthesia with lidocaine and epinephrine in a patient with chronic renal failure. Anesth Analg 63: 636, 1984

    Article  Google Scholar 

  45. Vandam LD, Harrison JH, Murray JE, Merrill JP: Anesthesia aspects of renal homotransplantation in man. Anesthesiology 23: 783, 1962

    Article  PubMed  CAS  Google Scholar 

  46. Wyant GM: The anaesthetist looks at tissue transplantation: three years’ experience with kidney transplants. Can Anaesth Soc J 14:255, 1967

    Article  PubMed  CAS  Google Scholar 

  47. Merin RG, Linke CL: Regional anaesthesia for renal transplantation. Reg Anaesth 4: 13, 1979

    Google Scholar 

  48. Maddern PJ: Anaesthesia for the patient with impaired renal function. Anaesth Intensive Care 11: 321, 1983

    PubMed  CAS  Google Scholar 

  49. Halperin BD, Feeley TV: The effects of anesthesia and surgery on renal function in International Anesthesiology Clinics, 22, no 1, edited by Prieb HF, Boston, Little Brown and Co, 1984

    Google Scholar 

  50. Bromage PR: Physiology and pharmacology of local analgesia. Anesthesiology 28: 592, 1967

    PubMed  CAS  Google Scholar 

  51. Gould DB, Aldrete JA: Bupivacaine cardiotoxicity in a patient with renal failure. Acta Anaesthesiol Scand 27: 18, 1983

    Article  PubMed  CAS  Google Scholar 

  52. Weir PHC, Chung FF: Anaesthesia for patients with chronic renal disease. Canad Anaesth Soc J 31: 468, 1984

    Article  PubMed  CAS  Google Scholar 

  53. Lynn RB, Sancetta SM, Simeone FA, Scott RW: Observations on the circulation in high spinal anesthesia. Surgery 32: 195, 1951

    Google Scholar 

  54. Kennedy WF, Sawyer TK, Gerbershagen HV, Cutler RE, Allen GD, Bonica JJ: Systemic cardiovascular and renal hemodynamic alterations during peridural anesthesia in normal man. Anesthesiology 31: 414, 1969

    Article  PubMed  CAS  Google Scholar 

  55. Kennedy WF, Sawyer TK, Gerbershagen HV, Everett GB, Cutler RE, Allen GD, Bonica JJ: Simultaneous systemic cardiovascular and renal hemodynamic measurements during high spinal anesthesia in normal man. Acta Anaesth Scand, Suppl 37: 163, 1970

    Google Scholar 

  56. Sivarajan M, Avory DW, Lindblook LE, Schwettmann RS: Systemic and regional blood flow changes during spinal anesthesia in the Rhesus monkey. Anesthesiology 43: 78, 1975

    Article  PubMed  CAS  Google Scholar 

  57. Sivarajan M, Avory DW, Lindblook LE: Systemic and regional blood flow during epidural analgesia without epinephrine in the Rhesus monkey. Anesthesiology 45: 300, 1976

    Article  PubMed  CAS  Google Scholar 

  58. Moran WH, Miltenberger FW, Shuayb WA, Zimmermann B: The relationship of antidiuretic hormone to surgical stress. Surgery 56: 99, 1964

    Google Scholar 

  59. Zideman DA, Bevan DR, Dudley HAF: Osmolar output in the perioperative period. Anaesthesia 33: 788, 1978

    Article  PubMed  CAS  Google Scholar 

  60. Bevan DR: Renal Function in Anaesthesia and Surgery. London, Academic Press, New York, Grune and Stratton, 1979

    Google Scholar 

  61. Truniger B, Rosen SM, Grandchamp A, Strebel H, Kriek HR: Redistribution of renal blood flow in haemorrhagic hypotension. Role of renal nerves and catecholamines. Eur J Clin Invest 1: 277, 1971

    PubMed  CAS  Google Scholar 

  62. Johnson MD, Park CS, Malvin RL: Antidiuretic hormone and the distribution of renal cortical flow. Am J Physiol 232: Fill, 1977

    Google Scholar 

  63. Hutchin P, Terzi RG, Holandsworth LC: Renal response to intraoperative fluid administration. Surg Gynec Obstet 129: 794, 1969

    PubMed  CAS  Google Scholar 

  64. Shire T, Williams J, Brown F: Acute changes in extracellular fluids associated with major surgical procedures. Ann Surg 154: 803, 1961

    Article  Google Scholar 

  65. Roth E, Lax LC, Maloney JV: Ringer’s lactate solution and extracellular fluid volume in the surgical patient: a critical analysis. Ann Surg 169: 149, 1969

    Article  PubMed  CAS  Google Scholar 

  66. Robertson D, Michelakis AM: Effect of anesthesia and surgery on plasma renin activity in man. J Clin Endocrinol Metab 34: 831, 1972

    Article  PubMed  CAS  Google Scholar 

  67. Bailey DR, Miller ED, Kaplan JA, Rogers PW: The reninangiotenin-aldosterone system during cardiac surgery with morphine-nitrous oxide anesthesia. Anesthesiology 42: 538, 1975

    Article  PubMed  CAS  Google Scholar 

  68. Inturrisi CE: Disposition of narcotics in patients with renal disease. Am J Med 62: 528, 1977

    Article  PubMed  CAS  Google Scholar 

  69. Olsen GD, Bennett WM, Porter GA: Morphine and phenytoin binding to plasma proteins in renal and hepatic failure. Clin Pharmacol Ther 17: 677, 1977

    Google Scholar 

  70. Bennett WM: Prescribing drugs for patients with reduced renal function, in Drugs and Renal Disease, edited by Bennett WM, 2nd edition, New York, Edinburg, London, Melbourne Churchil Livingstone, 1986, p 26

    Google Scholar 

  71. Dundee JW, Richards RK: Effect of azotemia upon the action of intravenous barbiturate anesthesia. Anesthesiology 15: 333, 1954

    Article  PubMed  CAS  Google Scholar 

  72. Gnoneim MM, Pandya H: Plasma protein binding of thiopental in patients with impaired renal or hepatic function. Anesthesiology 42: 545, 1975

    Article  Google Scholar 

  73. Freeman RB, Sheff MF, Maher JF, Schreiner GE: The blood- cerebrospinal fluid barrier in uremia. Ann Intern Med 56: 233, 1962

    PubMed  CAS  Google Scholar 

  74. Smith CL, Hunter JM, Jones RS: Vecuronium infusions in patients with renal failure in an ITU. Anaesthesia 42: 387, 1987

    Article  PubMed  CAS  Google Scholar 

  75. Hunter JM, Jones RS, Utting JE: Use of atracurium in patients with no renal function. Br J Anaesth 54: 1251, 1982

    Article  PubMed  CAS  Google Scholar 

  76. Hunter JM, Jones RS, Utting JE: Comparison of vecuronium, atracurium and tubocurarine in normal patients and in patients with no renal function. Br J Anaesth 56: 941, 1984

    Article  PubMed  CAS  Google Scholar 

  77. Koide M, Waud BE: Serum potassium concentrations after succinylcholine in patients with renal failure. Anesthesiology 36: 142, 1972

    Article  PubMed  CAS  Google Scholar 

  78. Miller RD, Way WL, Hamilton WK, Layzer RB: Succinylcholine-induced hyperkalemia in patients with renal failure. Anesthesiology 36: 138, 1972

    Article  PubMed  CAS  Google Scholar 

  79. Cronnelly R, Stanski DR, Miller DR, Sheiner LB, Sohn YJ: Renal function and the pharmacokinetics of neostigmine in anesthetized man. Anesthesiology 51: 222, 1979

    Article  PubMed  CAS  Google Scholar 

  80. Bishop MJ, Hornbein TF: Prolonged effect of succinylcholine after neostigmine and pyridostigmine administration in patients with renal failure. Anesthesiology 58: 284, 1979

    Google Scholar 

  81. Tasker PRW, MacGregor GA, DeWardener HE: Prophylactic use of intravenous saline in patients with chronic renal failure undergoing major surgery. Lancet 2: 911, 1974

    Article  PubMed  CAS  Google Scholar 

  82. Morris PJ: Blood transfusions and transplantation. Transplantation 26: 276, 1978

    PubMed  CAS  Google Scholar 

  83. Van Rood J: Blood transfusion and transplantation. Transplantation 26: 275, 1978

    Article  PubMed  Google Scholar 

  84. Opelz G, Terasaki PI: Dominant effects of transfusions on kidney graft survival. Transplantation 29: 153, 1980

    Article  PubMed  CAS  Google Scholar 

  85. Breimer DD, Jochemsen R, Von Albert HH: Pharmacokinetics of benzodiazepines. Drug Research 30: 875, 1980

    PubMed  CAS  Google Scholar 

  86. Becker ID, Paulson BA, Miller RD, Severinghaus JW, Eger EI: Biphasic respiratory depression after fentanyl-droperidol or fentanyl alone used to supplement nitrous oxide anesthesia. Anesthesiology 44: 291, 1976

    Article  PubMed  CAS  Google Scholar 

  87. Wiggum DC, Cork RC, Weldon ST, Gandolfi AJ, Perry DS: Postoperative respiratory depression and elevated sufentanil levels in a patient with chronic renal failure. Anesthesiology 63: 708, 1985

    Article  PubMed  CAS  Google Scholar 

  88. Morgan M, Lumley J: Anaesthetic considerations in chronic renal failure. Anaesth Intensive Care 3: 218, 1975

    PubMed  CAS  Google Scholar 

  89. Charters P: Renal transplantation in diabetes mellitus. Anesthesiology 63: 708, 1985

    Article  Google Scholar 

  90. Carlier M, Squifflet JP, Pirson Y, Gribomont B, Alexandre GPJ: Maximal hydration during anaesthesia increases pulmonary artery pressure and improves function of human renal transplant. Transplantation 34: 201, 1982

    Article  PubMed  CAS  Google Scholar 

  91. Goldberg LJ: Dopamine — clinical uses of an endogenous catecholamine. N Engl J Med 291: 707, 1974

    Article  PubMed  CAS  Google Scholar 

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Utting, J.E. (1989). Anaesthesia and Major Surgery in Patients with Renal Failure. In: Maher, J.F. (eds) Replacement of Renal Function by Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1087-4_52

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  • DOI: https://doi.org/10.1007/978-94-009-1087-4_52

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