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Indications, Selection, and Management of the Recipient

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The Transplantation and Replacement of Thoracic Organs

Abstract

Successful heart—lung transplantation can be dated to the beginning of the present decade, with the first reported case performed for primary pulmonary hypertension in 19811. Since then there has been a steady increase in the number of operations performed2, and a broadening of the indications for the procedure. The indications for transplantation of the heart and both lungs overlap to a certain extent on the one hand with those for cardiac transplantation, and, on the other hand, with those for single or double lung transplantation. This chapter will include our experience of transplantation at Harefield Hospital, where the first heart—lung procedure was performed in September, 1984. Since that time, 176 patients have received heart and lungs, and, of these, nine have requried retransplantation for obliterative bronchiolitis.

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References

  1. Reitz, B.A., Wallwork, J.L, Hunt, S.A., Pennock, J.L., Billingham, M.E., Oyer, P.E., Stinson, E.B. and Shumway, N.E. (1982). Heart-lung transplantation. N. Engl J. Med., 306, 557

    Article  PubMed  CAS  Google Scholar 

  2. Kaye, M.P. (1987). The Registry of the International Society for Heart Transplantation: fourth official report — 1987. J. Heart Transplant., 6, 63

    PubMed  CAS  Google Scholar 

  3. Scott, J.P., Hutter, J.A., Higenbottam, T.W. and Wallwork, J. (1988). Combined heart and lung transplantation. Cardiol. Practice., 6, 21

    Google Scholar 

  4. Griffith, B.P., Hardesty, R.L., Trento, A., Paradis, I.L, Duquesnoy, R.J., Zeevi, A., Dauber, J.H., Dummer, J.S., Thompson, M.E., Gryzan, S. and Bahnson, H.T. (1987). Heart-lung transplantation: lessons learned and future hopes. Ann. Thorac. Surg., 43, 6

    Article  PubMed  CAS  Google Scholar 

  5. Burke, C.M., Theodore, J., Baldwin, J.C., Morris, A.J., McGregor, C., Shumway, N.E., Robin, E.D. and Jamieson, S.W. (1986). Twenty-eight cases of human heart—lung transplantation. Lancet., 1, 517

    Article  PubMed  CAS  Google Scholar 

  6. Primo, G., Wellens, F., Leclerc, J.L. and De Smet, J.M. (1986). Current indications and experience with heart—lung transplantation. Transplant. Proc., (Suppl. 3), 41

    Google Scholar 

  7. Hutchison, D.C.S. (1988). Natural history of α1-protease inhibitor deficiency. Am. J. Med., 84, 3

    PubMed  CAS  Google Scholar 

  8. Wellens, F., Estenne, M., De Francquen, P., Goldstein, J., Leclerc, J.L. and Primo, J. (1985). Combined heart—lung transplantation for terminal pulmonary lymphangioleiomyomatosis. J. Thorac. Cardiovasc. Surg., 89, 872

    PubMed  CAS  Google Scholar 

  9. Cooper, J.D., Pearson, F.G., Patterson, G.A., Todd, T.R.J., Ginsberg, R.J., Goldberg, M. and Demajo, W.A.P. (1987). Technique of successful lung transplantation in humans. J. Thorac. Cardiovasc. Surg., 93, 173

    PubMed  CAS  Google Scholar 

  10. Wallwork, J., Williams, R. and Calne, R.Y. (1987). Transplantation of liver, heart and lungs for primary biliary cirrhosis and primary pulmonary hypertension. Lancet., 2, 182

    Article  PubMed  CAS  Google Scholar 

  11. Aravot, D.J., Banner, N.R., Khagani, A., Fitzgerald, M., Radley-Smith, R., Mitchell, A.G. and Yacoub, M.H. (1989). Cardiac transplantation in the seventh decade of life. Am. J. Cardiol., 63, 90

    Article  PubMed  CAS  Google Scholar 

  12. Hakim, M., Wreghitt, T., English, T.A.H., Stovin, P.G.I, Cory-Pearce, R. and Wallwork, J. (1985). Significance of donor transmitted disease in cardiac transplantation. J. Heart Transplant., 4, 302

    PubMed  CAS  Google Scholar 

  13. Mootoosamy, I.M., Reznek, R.M., Osman, J., Rees, R.S. and Green, M. (1985). Assessment of bronchiectasis by computerized tomography. Thorax, 40, 920

    Article  PubMed  CAS  Google Scholar 

  14. Hakim, M., Higenbottam, T., Bethune, D., Cory-Pearce, R., English, T.A.H., Kneeshaw, J., Wells, F.C. and Wallwork, J. (1988). Selection and procurement of combined heart and lung grafts for transplantation. J. Thorac. Cardiovasc. Surg., 95, 474

    PubMed  CAS  Google Scholar 

  15. Perlmutt, L.M., Braun, S.D., Newman, G.E., Oke, E.J. and Dunnick, N.R. (1987). Pulmonary arteriography in the high-risk patient. Radiology, 162, 187

    PubMed  CAS  Google Scholar 

  16. Fuster, V., Steele, P.M., Edwards, W.D., Gersh, B.J, McGoon, M.D. and Frye, R.L. (1984). Primary pulmonary hypertension: natural history and the importance of thrombosis. Circulation, 70, 580

    Article  PubMed  CAS  Google Scholar 

  17. Rozkovec, A, Montanes, P. and Oakley, C.M. (1986). Factors that influence the outcome of primary pulmonary hypertension. Br. Heart J., 55, 449

    Article  PubMed  CAS  Google Scholar 

  18. Jones, D.K, Higenbottam, T. and Wallwork, J. (1987). Treatment of primary pulmonary hypertension with intravenous epoprostenol (prostacycline). Br. Heart J., 57, 270

    Article  PubMed  CAS  Google Scholar 

  19. Stead, R.J, Davidson, T.I, Duncan, F.R, Hodson, M. and Batten, J.C. (1987). Use of a totally implantable system for venous access in cystic fibrosis. Thorax, 42, 149

    Article  PubMed  CAS  Google Scholar 

  20. Hodson, M.E, Wise, A.E, Duncan, F. and Batten, J.C. (1985). Factors affecting survival of adult patients with cystic fibrosis. Thorax, 40, 227

    Google Scholar 

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Authors
  1. A. G. Mitchell
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Editors and Affiliations

  1. Baptist Medical Center, Oklahoma Transplantation Institute, Oklahoma City, Oklahoma, USA

    David K. C. Cooper MA, MD, PhD, FRCS (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) & Dimitri Novitzky MD, FCS (SA) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery) (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) &  (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery)

  2. University of Cape Town Medical School and Groote Schuur Hospital, Cape Town, South Africa

    David K. C. Cooper MA, MD, PhD, FRCS (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery) (Cardiothoracic Surgeon and Director of Research and Education, Formerly, Associate Professor of Cardiothoracic Surgery)

  3. Groote Schuur Hospital, Cape Town, South Africa

    Dimitri Novitzky MD, FCS (SA) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery) (Cardiothoracic Surgeon, Formerly, Specialist in Cardiothoracic Surgery)

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© 1990 Kluwer Academic Publishers

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Mitchell, A.G. (1990). Indications, Selection, and Management of the Recipient. In: Cooper, D.K.C., Novitzky, D. (eds) The Transplantation and Replacement of Thoracic Organs. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0711-9_34

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  • DOI: https://doi.org/10.1007/978-94-009-0711-9_34

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6805-5

  • Online ISBN: 978-94-009-0711-9

  • eBook Packages: Springer Book Archive

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