Skip to main content

Abstract

The relationships between inflammation and pain were known for a long time, even by antique civilizations. However most of the fundamental knowledge about biological mechanisms explaining some of the links between inflammation and nociception processes have been discovered over the last three decades. Peripheral infection or injury can induce an inflammation and related pain but also some nerves, especially C fibers which are mainly involved in nociception transmission, can generate a so called “neurogenic inflammation”. New findings rise some questions about the role of magnesium (Mg) in these two phenomena.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Kruse, H.D., Orent, E.R., Mc Collum, E.V. (1932): Studies on magnesium deficiency in animals.I. Symptomatology resulting from magnesium deprivation. J. Biol. Chem., 96: 519–539.

    Google Scholar 

  2. Bois, P., Gascon, A., Beaulnes, A. (1963) Hislamine-liberating effect of magnesium deficiency in the rat. Nature, 197: 501–502.

    Article  CAS  Google Scholar 

  3. Nishio A., Ishiguro S., Ikegaki I., Matsumoto S., Yoshimitsu F. and Miyazaki A. (1988): Histamine metabolism and pinnal hyperaemia during magnesium deficiency in rats, Magnes. Res, 1: 155–161.

    CAS  Google Scholar 

  4. Rayssiguier, Y., Malpuech, C., Nowacki, W., Daveau, M., Lebreton, J.P., Rock, E., Mazur, A., Geueux, E. (1994), Evaluation of the inflammatory state during magnesium deficiency in the rat, Magnes. Res., 7, 51

    Google Scholar 

  5. Kimball, E.S. (1991): Cytokines and inflammation, CRC Press.

    Google Scholar 

  6. Weglicki W.B., Phillips T.M. (1992); Pathobiology of magnesium deficiency; a cytokine/neurogenic inflammation hypothesis, Am J Physiol, 263: R734–R737.

    CAS  Google Scholar 

  7. Weglicki W.B., Phillips T.M., Freedman A.M., Cassidy M.M., Dickens B.F.(1992): Magnesium–deficiency elevates circulating levels of inflammatory cytokines and endothelin, Mol Cell Biochem, 110: 169–173.

    Article  CAS  Google Scholar 

  8. Weglicki W.B., Stafford R.E., Dickens B.F., Mak I.T., Cassidy M.M., Phillips T.M., (1993):Inhibition of tumor necrosis factor-alpha by thalidomide in magnesium deficiency, Mol Cell Biochem, 129; 195–200.

    Article  CAS  Google Scholar 

  9. Rayssiguier, Y., Gueux, E., Bussiere, L., Durlach, J., Mazur, A. (1993):Dietary magnesium affects susceptibility of lipoproteins and tissues to peroxidation in rats, J. Am. Coll. Nutr. 12, 133–137.

    CAS  Google Scholar 

  10. Rayssiguier, Y., Durlach, J., Gueux E, Rock, E. and Mazur, A. (1993), Magnesium and ageing I. Experimental data: importance of oxidative damage, Magnes. Res. 6: 369–378.

    CAS  Google Scholar 

  11. Durlach, J., Durlach, V., Bac, P., Rayssiguier, Y., Bara, M., Guiet-Bara, A., (1993): Magnesium and ageing II Clinical data: aetiological mechanisms and pathophysiological consequences of magnesium deficit in the elderly, Magnes. Res. 6: 379–394.

    CAS  Google Scholar 

  12. Weglicki, W.B., Phillips T.M., Mak, I.T., Cassidy M.M., Dickens B.F., Stafford R., Kramer, J.H.(1994): Cytokines, neuropeptides, and reperfusion injury during magnesium deficiency, Annals. New York Academy Sc., 723: 246–257.

    Article  CAS  Google Scholar 

  13. Meller, S.T., Gebhart, G.F.(1993): Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain, 52: 127–136.

    Article  CAS  Google Scholar 

  14. Rock, E., Astier C., Lab, C., Malpuech, C., Nowacki, W., Gueux, E., Mazur, A., Rayssiguier, Y. (1995): Magnesium deficiency in rats induces a rise in plasma nitric oxide, Magnes. Res. 8; 237–242.

    CAS  Google Scholar 

  15. Rock E., Astier, C., Lab, C., Vignon, X., Gueux E., Motta, C., Rayssiguier, Y.(1995): Dietary magnesium deficiency in rats enhances free radical production in skeletal muscle, J. Nutr., 125: 1205–1210.

    CAS  Google Scholar 

  16. Peplow, P.V.(1992): Modification to dietary intake of sodium, potassium, calcium, magnesium and trace elements can influence arachidonic acid metabolism and eicosanoid production, Prostaglandins Leuko trienes and Essential Fatty Acids, 45, 1–19.

    Article  CAS  Google Scholar 

  17. Weglicki, W.B., Mak, I.T., Kramer, J.H, Dickens, B.F., Cassidy, M.M., Stafford R.E., Phillips T.M. (1995): Role of free radicals and substance P in magnesium deficiency, Cardiovasc Res. 31: 677–682.

    Google Scholar 

  18. Weglicki W.B., Dickens B.F., Wagner T.L., Chmielinska, J.J., Phillips, T.M.(1996): Immunoregulation by neuropeptides in magnesium deficiency; ex vivo effect of enhanced substance P production on circulating T Lymphocytes from magnesium-deficient mice, Magnes. Res. 9: 3–11.

    CAS  Google Scholar 

  19. Prouvost-Danon A., Larvor, P., Rayssiguier, Y et al., (1975): Taux serique d’ anticorps reaginiques (IgE) chez la souris en carence magnesique, Rev. Fr. Allergol. 15: 147–150.

    Google Scholar 

  20. Kawanobe, Y. and Sakamoto, M. (1989): Complement systems and phagocytic activities in magnesium deficient rats, Magnes. Res. 2: 81

    Google Scholar 

  21. Iseri, L.T. and French, J.H. (1984): Magnesium: Nature’s physiologic calcium blocker, Am. Heart J. 108; 188–193.

    Article  CAS  Google Scholar 

  22. Hill, R.G.(1991); Criteria for the development of analgesic drugs: a personal view from the perspective of the pharmaceutical industry. In; A.I. Basbaum and J.M. Besson (Eds), Towards a New Pharmacotherapy of Pain, John Wiley and Sons, Chichester, pp. 293–329.

    Google Scholar 

  23. Haves, A.G., Scadding, W., Skingle, M., Tyers, M.B. (1981): Effects of neonatal administration of capsaicin on nociceptive thresholds in the mouse and rat, J. Pharm. Pharmacol. 33: 183–185.

    Google Scholar 

  24. IASP (1994): Classification of Chronic Pain, 2d Edition, IASP Task Force on Taxonomy, H. Merskey and N. Bogduk (eds.), IASP Press, Seattle, pp. 209–214.

    Google Scholar 

  25. Dubray, C., Alloui, A., Bardin, L., Rock E., Mazur, A., Rayssiguier, Y., Eschalier, A., Lavarenne, J. (1997): Magnesium deficiency induces an hyperalgesia reversed by the NMDA receptor antagonist MK801, Neuroreport, 8: 1383–1386.

    Article  Google Scholar 

  26. Woolf, C.J., Thompson, S.W.N.(1991): The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of pos-injury hypersensitivity states. Pain, 44: 293–299.

    Article  CAS  Google Scholar 

  27. Dickenson, A.H., (1994): NMDA receptor antagonists as analgesics, In: HL Fields, and JC Liebeskind, (eds.) Prog. Pain research and Management. Seattle: IASP Press, pp. 173–187.

    Google Scholar 

  28. McMahon, SB., Lewin, G.R., Wall, P.D (1993): Central excitability triggered by noxious inputs. Current Opinion Neurobiol. 3: 602–610.

    Article  CAS  Google Scholar 

  29. Kawajiri, S., Dingledine, R. (1993): Multiple strucrural determinants of voltage-depended magnesium block in recombinant NMDA receptors. Neuropharmacology, 32: 1203–1211.

    Article  CAS  Google Scholar 

  30. Arancio, O., Yoshimura, M., Murase, K., MacDermott, A.B. (1993): The distribution of excitatory amino acid receptors on acutely dissociated dorsal horn neurons from postnatal rats, Neuroscience, 52; 159–167.

    Article  CAS  Google Scholar 

  31. Henley, J.M., Jenkins, R., Hunt, S.P. (1993): Localisation of glutamate receptor binding sites and mRNAs to the dorsal horn of the rat spinal cord, Neuropharmacology, 32: 37–41.

    Article  CAS  Google Scholar 

  32. Burnashev, N., Schoepfer, R., Monyer, H., Ruppersberg, J.P., Gunther, W., Seeburg, P.H., Sakmann, B. (1992): Control by asparagine residues of calcium permeability and magnesium Blockade in the NMDA receptor. Science. 257; 1415–1419.

    Article  CAS  Google Scholar 

  33. Bac P., Herrenknecht, C., Dupont, Ch.(1996) effects of magnesium acetyltaurinate and morphine hydrochloride on hot plate test in magnesium deficient mice, XXIVeme Colloque Francais Annuel sur le magnesium, November 1996.

    Google Scholar 

  34. Poenaru, S., Rouhani, S., Durlach, J., Aymard, N., Belkahla, F., Rayssiguier, Y. Iovino, M. (1984): Vigilance states and cerebral monoamine metabolism in experimental magnesium deficiency, Magnesium, 3: 145–151.

    CAS  Google Scholar 

  35. Mauskop, A., Altura, B.T., Cracco, R.Q. Altura, B.M.(1996): Intravenous magnesium sulfate rapidly allebiates headaches of various types, Headache, 36: 154–160.

    Article  CAS  Google Scholar 

  36. Luthringer, C., Rayssiguier, Y., Gueux, E., Berthelot, A. (1988): Effect of moderate magnesium deficiency on serum lipids, blood pressure and cardiovascular reactivity in normotensive rats, Br J Nutr, 59: 243–250

    Article  CAS  Google Scholar 

  37. Henrotte, J.G., Pla, M., Dausset, J. (1990) HLA- and H-2-associated variations of intra-and extracellular magnesium content, Proc Natl Acad Sci USA, 87: 1894–1898.

    Article  CAS  Google Scholar 

  38. Laroche, M., Ginesty, E., Serrano, E., Cantagrel, A., Bon, E., Moulinier, L., Mazieres, B. (1997): Inflammatory rheumatism and nasal polyposis, Clin. Rheumatol., 16: 207–211.

    Article  CAS  Google Scholar 

  39. Xiao, W.H., Bennett, G.J.(1994): Magnesium suppresses neuropathic pain responses in rats via a spinal site of action, Brain Res., 666: 168–172

    Article  CAS  Google Scholar 

  40. Sato, E., Takano, Y., Takano, M., Kuno, Y., and Sate, I. (1996): The antinociceptive effect of intrathecally administered magnesium sulfate in rats, 8 th World Congress on Pain August 17–22, 1996, Vancouver, British Columbia, Canada.

    Google Scholar 

  41. Tramer, M.R., Schneider, J., Marti, R.A., Rifat, K.(1996): Role of magnesium sulfate in postoperative analgesia, Anesthesiology, 84: 340–347.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Kluwer Academic Publishers

About this chapter

Cite this chapter

Dubray, C., Rayssiguier, Y. (1997). Magnesium, Inflammation and Pain. In: Theophanides, T., Anastassopoulou, J. (eds) Magnesium: Current Status and New Developments. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0057-8_63

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-0057-8_63

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6515-3

  • Online ISBN: 978-94-009-0057-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics