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Use of Radiolabeled Compounds and Imaging as Cardiac Biomarkers

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General Methods in Biomarker Research and their Applications

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Abstract

Specific molecules that are labelled with radioactive isotopes can be injected in very small quantities into a living organism for in vivo, minimally invasive imaging without evoking a physiologic response. These molecules are aptly referred to as tracers, and images of their biodistribution provide information on the presence of disease and insight into biochemical processes. A wide range of tracers and applications have been developed for cardiac indications, and ongoing research is expending the field. This chapter summarizes current applications and the state of the art of radiolabeled compounds in imaging of cardiac biomarkers.

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Abbreviations

CAD:

Coronary artery disease

CPT:

Cold pressor test

ECG:

Electrocardiogram

EDV:

End diastolic volume

EF:

Ejection fraction

ESV:

End systolic volume

LV:

Left ventricle

MBF:

Myocardial blood flow

MFR:

Myocardial flow reserve

MPI:

Myocardial perfusion imaging

MUGA:

Multiple-gated acquisition

PET:

Positron emission tomography

ROI:

Region of interest

RV:

Right ventricle

SPECT:

Single-photon emission computed tomography

SUV:

Standard uptake value

TAC:

Time-activity curve (of tracer concentration)

VEGF:

Vascular endothelial growth factor

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Authors and Affiliations

  1. Department of Nuclear Medicine, The Ottawa Hospital, 2053 Ruskin St, Ottawa, ON, K1Y 4W7, Canada

    Ran Klein

  2. Physics Department, Department of Cardiology, Carleton University, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, K1Y 4W7, Canada

    Amir Pourmoghaddas

  3. Department of Cardiology, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, K1Y 4W7, Canada

    Brian Mc Ardle & Benjamin J. W. Chow

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  1. Ran Klein
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  2. Amir Pourmoghaddas
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  3. Brian Mc Ardle
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  4. Benjamin J. W. Chow
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Correspondence to Ran Klein .

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Editors and Affiliations

  1. Diabetes & Nutritional Sciences Division, King's College, London, United Kingdom

    Victor R. Preedy

  2. Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, United Kingdom

    Vinood B. Patel

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Klein, R., Pourmoghaddas, A., Mc Ardle, B., Chow, B.J.W. (2014). Use of Radiolabeled Compounds and Imaging as Cardiac Biomarkers. In: Preedy, V., Patel, V. (eds) General Methods in Biomarker Research and their Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7740-8_37-1

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  • DOI: https://doi.org/10.1007/978-94-007-7740-8_37-1

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