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Urinary Hydrogen Peroxide as Biomarker

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General Methods in Biomarker Research and their Applications

Abstract

Hydrogen peroxide can be found in human urine, not only in persons with diseases, but also in healthy individuals. In the body, hydrogen peroxide plays dual roles: on the one hand, it can produce more dangerous reactive oxygen species – hydroxyl radicals, which cause damage to the cells; on the other hand, it is considered as “a signaling molecule” to regulate the cellular processes. In this chapter, we will review the literature linking H2O2 excretion in urine of healthy individuals and of persons with diseases and present the available methods that have been used for detection of urinary H2O2 in human. We also give a brief overview on the association of urinary levels of H2O2 with other oxidative stress biomarkers and discuss the possibility whether urinary H2O2 could be a useful biomarker for the assessment of the oxidative status in human and for the prediction of the pathogenesis and progression of diseases.

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Authors and Affiliations

  1. Department of Public Health, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan

    Da-Hong Wang, Keiki Ogino, Masayuki Kubo, Kei Takemoto & Chie Masatomi

  2. Graduate School of Health Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan

    Yoshie Sato

  3. Department of Gerontology Research, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan

    Noriko Sakano

Authors
  1. Da-Hong Wang
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  2. Keiki Ogino
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  3. Yoshie Sato
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  4. Noriko Sakano
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  5. Masayuki Kubo
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  6. Kei Takemoto
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  7. Chie Masatomi
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Correspondence to Keiki Ogino .

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Editors and Affiliations

  1. Department of Nutrition and Dietetics, Division of Diabetes & Nutritional Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom

    Victor R. Preedy

  2. Faculty of Science & Technology, Department of Biomedical Sciences, University of Westminster, London, United Kingdom

    Vinood B. Patel

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Wang, DH. et al. (2015). Urinary Hydrogen Peroxide as Biomarker. In: Preedy, V., Patel, V. (eds) General Methods in Biomarker Research and their Applications. Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7696-8_43

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