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Role of Cyclooxygenase-2 in the Development and Growth of Schwannomas

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Tumors of the Central Nervous System, Volume 13

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 13))

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Abstract

Recently, numerous experimental reports as well as clinical trials suggested a possible therapeutic role of selective cyclooxygenase-2 (COX-2) inhibitors in the treatment of various tumors. COX-2 is known to convert procarcinogens to carcinogens and is upregulated in several malignant tumors. Its overexpression seems to correlate with aggressive disease and poor survival. In human schwannomas, COX-2 expression was observed in the cytoplasma and perinuclear regions of tumor cells. The available data suggests involvement of COX-2 in the development and growth of human schwannomas by regulating angiogenic factors and inhibition of tumor cell apoptosis by production of prostaglandins, particularly PGE2. Furthermore, diverse neurotrophic factors have been also suggested a biological role in development, maintenance, and growth of schwannomas. Selective COX-2 inhibitors have a potential role for targeted therapy against schwannomas.

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Authors and Affiliations

  1. Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany

    Bujung Hong, Makoto Nakamura & Joachim K. Krauss

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  1. Bujung Hong
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  2. Makoto Nakamura
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  3. Joachim K. Krauss
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Correspondence to Bujung Hong .

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Editors and Affiliations

  1. Department of Biological Sciences, Kean University, Room 213, Library Building, Union, New Jersey, USA

    M.A. Hayat

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Hong, B., Nakamura, M., Krauss, J.K. (2014). Role of Cyclooxygenase-2 in the Development and Growth of Schwannomas. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 13. Tumors of the Central Nervous System, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7602-9_5

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  • DOI: https://doi.org/10.1007/978-94-007-7602-9_5

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