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Endothelial Cell Toxicity of Vascular Apoptosis-Inducing Proteins from Hemorrhagic Snake Venom

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Snake Venoms

Part of the book series: Toxinology ((TOXI))

Abstract

Vascular apoptosis-inducing protein (VAP) is a protein family in hemorrhagic snake venom which induces apoptosis in vascular endothelial cells. It belongs to snake venom metalloprotease (SVMP) and therefore to a disintegrin and metalloprotease (ADAM) family. There is a large amount of VAPs in hemorrhagic snake venom. In addition to their hemorrhagic activity, VAPs have some special activities on vascular endothelial cells including the apoptosis-inducing effect. One of the special activities is cell fragmentation in apoptosis. VAPs also induce detachment of cell-cell contacts and morphological changes with protrusion in vascular endothelial cells. Although the receptor or target molecule of VAPs in endothelial cells is not well known, VAPs are supposed to have some important functions against cells. VAPs may play roles in resolving the hemorrhagic snake venom mechanism, as well as resolving the vascular endothelial cell functions in mammalian body.

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  1. Department of Science, Nagoya University, Furocho, Chikusa-ku, 464-8602, Nagoya, Japan

    Satohiko Araki

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Correspondence to Satohiko Araki .

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  1. Biomedical Research Institute National Institute of Advanced Industria, Tsukuba, Ibaraki, Japan

    Hidetoshi Inagaki

  2. University of Hawaii Cancer Center, Honolulu, Hawaii, USA

    Carl-Wilhelm Vogel

  3. Department of Molecular Biology and Biot, Tezpur University, Tezpur, Assam, India

    Ashis K. Mukherjee

  4. Egyptian Society of Natural Toxins and Z, Faculty of Science Suez Canal University, Ismailia, Egypt

    Tarek R. Rahmy

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© 2017 Springer Science+Business Media Dordrecht

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Araki, S. (2017). Endothelial Cell Toxicity of Vascular Apoptosis-Inducing Proteins from Hemorrhagic Snake Venom. In: Inagaki, H., Vogel, CW., Mukherjee, A., Rahmy, T. (eds) Snake Venoms. Toxinology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6410-1_5

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