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Spinal Cord Injury: Tissue Engineering Using Neural Stem Cells

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Tumors of the Central Nervous System, Volume 10

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 10))

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Abstract

Spinal cord injuries result in catastrophic dysfunctions that impair the quality of a patient’s life. Following spinal cord injury (SCI), the cascade of cellular and biochemical reactions during primary and secondary injuries and a dense scar formation leads to a devastating physical and chemical barrier at the lesion site. These effects could not be reversed through conventional treatments. A multidisciplinary approach that includes materials science, engineering, biology, chemistry, and medicine is required to achieve a completely successful treatment for SCI. Tissue engineering, which integrates scaffolds, autologous (preferably) cells, and growth factors, is an encouraging development in the treatment of SCI which aims to replace and restore the anatomical and functional structure of the damaged spinal cord. Neural stem cells (NSCs), by differentiating into the cells of the nervous system, are a promising cell source for use in this challenging approach which has a great potential in the therapy of spinal cord injuries.

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Author information

Authors and Affiliations

  1. Department of Histology and Embryology, School of Medicine, Acibadem University, 34848, Istanbul, Turkey

    Deniz Yucel

  2. BIOMATEN, CoE in Biomaterials and Tissue Engineering, 06800, Ankara, Turkey

    Deniz Yucel, Irem Ayse Kanneci, Damla Arslantunali, Gamze Torun Kose & Vasif Hasirci

  3. Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University, 34755, Istanbul, Turkey

    Irem Ayse Kanneci & Gamze Torun Kose

  4. Department of Biotechnology, BIOMAT, Middle East Technical University, 06800, Ankara, Turkey

    Damla Arslantunali

  5. Departments of Biotechnology and Biological Sciences, BIOMAT, Middle East Technical University, 06800, Ankara, Turkey

    Vasif Hasirci

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  1. Deniz Yucel
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  2. Irem Ayse Kanneci
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  3. Damla Arslantunali
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  4. Gamze Torun Kose
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  5. Vasif Hasirci
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Correspondence to Deniz Yucel .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Yucel, D., Kanneci, I.A., Arslantunali, D., Kose, G.T., Hasirci, V. (2013). Spinal Cord Injury: Tissue Engineering Using Neural Stem Cells. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 10. Tumors of the Central Nervous System, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5681-6_29

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  • DOI: https://doi.org/10.1007/978-94-007-5681-6_29

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-5680-9

  • Online ISBN: 978-94-007-5681-6

  • eBook Packages: MedicineMedicine (R0)

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