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MicroRNA in Leukemias

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MicroRNA in Cancer

Abstract

MicroRNAs are a class of master gene regulators that are extensively deregulated in all leukemias. Distinctive miRNA signatures are expressed in each cytogenetically defined subtype of leukemia which play multifaceted roles in the genesis, pathobiology, progression and clinical outcome of this group of diseases. This chapter aims to provide a comprehensive review of the expression, regulation and cellular targets of the microRNAs in acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML) in order to understand the regulatory role of microRNA in the leukemias as well as to identify novel therapeutic targets.

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  1. Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 71, 77030, Houston, TX, USA

    Deepa Sampath Ph.D

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  1. and Molecular Biology, Stanley S. Scott Cancer Center, Department of Biochemistry, Perdido Street 1901, New Orleans, 70112, Louisiana, USA

    Suresh Alahari

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Sampath, D. (2013). MicroRNA in Leukemias. In: Alahari, S. (eds) MicroRNA in Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4655-8_7

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