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Interference with Estrogen Receptor-α by Dietary Components: Impact on the Balance Between Cell Proliferation and Cell Death

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Natural compounds as inducers of cell death

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Abstract

ER-α, a major estrogen receptor, is a ligand-regulated factor that is involved in the transcriptional control of various physiological processes, including cell proliferation (by inducing progression through the G1 phase of the cell cycle in estrogen-responsive tissues) and other effects that appear to occur too rapidly to be mediated by transcriptional activation of genes. Furthermore, increased levels of cyclin D1 in breast cancer cells correlate with overexpression of ER-α. Epidemiological data have suggested that the consumption of some dietary components offers beneficial health effects due to their estrogenic activity, and several classes of natural products that can modulate ER-α activity and promote apoptosis have been identified. Interference with ER-α activity affects a fine balance between cell proliferation and cell death, and might have significant chemopreventive effects. Thus, the activities of natural compounds that influence ER-α activity, especially dietary components, warrant thorough characterization and evaluation.

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Abbreviations

AF:

activating function

BCRP:

breast cancer resistance protein

CDK7:

cyclin-dependent kinase 7

DBD:

DNA binding domain

ER:

estrogen receptor

LBD:

ligand-binding domain

MAPK:

mitogen-activated protein kinase

MDR:

multi-drug resistance

PTEN:

phosphatase and tensin homologue deleted on chromosome ten

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Authors and Affiliations

  1. Cell Cycle Regulation Group, Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, A-1090, Vienna, Austria

    Józefa Węsierska-Gądek, Margarita Maurer & Oxana Komina

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  1. Józefa Węsierska-Gądek
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  2. Margarita Maurer
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  3. Oxana Komina
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Correspondence to Józefa Węsierska-Gądek .

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  1. , Laboratoire de Biologie Moléculaire et C, Hôpotal Kirchberg, Rue Edward Steichen 9, Steichen, L- 2540, Luxembourg

    Marc Diederich

  2. , Laboratoire de Biologie Moléculaire et C, Hôpotal Kirchberg, Rue Edward Steichen 9, Steichen, L- 2540, Luxembourg

    Karoline Noworyta

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Węsierska-Gądek, J., Maurer, M., Komina, O. (2012). Interference with Estrogen Receptor-α by Dietary Components: Impact on the Balance Between Cell Proliferation and Cell Death. In: Diederich, M., Noworyta, K. (eds) Natural compounds as inducers of cell death. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4575-9_17

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