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Modelling Neurodegenerative Diseases Using Pluripotent Stem Cells

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Stem Cells and Cancer Stem Cells, Volume 6

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 6))

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Abstract

In order to gain greater insight into the molecular basis of neurological disease, scientists have been restricted primarily to genetically malleable animal models. However, for a number of reasons including genetic differences between humans and animals, the field has needed additional systems to better recapitulate the human condition. In this chapter we will review the use of human pluripotent stem cells as an unlimited source of affected tissue that can be used to model disease. In addition, we will discuss how these models may allow us to better understand the mechanism of these diseases as well as influence the generation of treatments.

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Authors and Affiliations

  1. Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, BSB 409, 8701 Watertown Plank Rd, Milwaukee, WI, 53226, USA

    Jered V. McGivern & Allison D. Ebert

Authors
  1. Jered V. McGivern
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  2. Allison D. Ebert
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Correspondence to Allison D. Ebert .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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McGivern, J.V., Ebert, A.D. (2012). Modelling Neurodegenerative Diseases Using Pluripotent Stem Cells. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 6. Stem Cells and Cancer Stem Cells, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2993-3_37

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