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Donor Policies for Hematopoietic Stem Cell Transplantation

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Stem Cells and Cancer Stem Cells, Volume 6

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 6))

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Abstract

With the advent of more sophisticated transplantation techniques and rapid advancements in supportive care, allogeneic hematopoietic stem cell transplantation has become part of standard therapy for a variety of hematologic diseases. Improvements in allogeneic transplant outcomes are due largely to our enhanced capability of identifying better-matched donors. Donor-recipient HLA-matching remains of paramount importance in minimizing transplant-associated risks. Policies that safeguard donor welfare should focus on the establishment of adequate screening procedures and optimal stem cell harvesting strategies to minimize risks to the donor. The development of a protocol for the mobilization and collection of peripheral blood stem cells streamlined the donorship process and provided a less traumatic alternative to bone marrow harvesting. For patients without an adequately matched donor, umbilical cord blood is increasingly being utilized as an alternative source of hematopoietic stem cells despite the unique challenges associated with its maintenance, storage, and transport. As hematopoietic transplantation forges forward, issues pertaining to international donorship and donor compensation will need to be addressed.

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Authors and Affiliations

  1. Department of Medicine, University of Chicago, 5841 S. Maryland Ave. MC 2115, Chicago, IL, 60637, USA

    Donne Bennett D. Caces, Koen Van Besien, Andrew S. Artz & Lucy A. Godley

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  1. Donne Bennett D. Caces
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  2. Koen Van Besien
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  3. Andrew S. Artz
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  4. Lucy A. Godley
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Correspondence to Lucy A. Godley .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Caces, D.B.D., Van Besien, K., Artz, A.S., Godley, L.A. (2012). Donor Policies for Hematopoietic Stem Cell Transplantation. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 6. Stem Cells and Cancer Stem Cells, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2993-3_25

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