Definition
Biological breadboards (BBBs) are platforms that carry out the spatiotemporal manipulation of cell behavior related to cell adhesion and detachment (e.g., cell positioning, cell patterning, and cell motility control), thus offering a new, versatile tool for studies of cellular dynamics. The platforms are composed of an array of identical gold electrodes patterned on a Pyrex glass substrate. The gold electrodes are functionalized with arginine-glycine-aspartic acid (RGD)-terminated thiol to create a cytophilic surface, and the Pyrex glass substrate is modified with polyethylene glycol (PEG) to achieve a cytophobic one. In the BBBs, cell adhesion and detachment are controlled by the reductive desorption of a gold-alkanethiol self-assembled monolayer (SAM) with activation potential of −0.9 to −1.8 V.
Overview
Cell adhesion and detachment processes are mediated by complex biomolecules from both sides of the cell-matrix...
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Yoon, SH., Mofrad, M.R.K. (2012). Biological Breadboard Platform for Studies of Cellular Dynamics. In: Bhushan, B. (eds) Encyclopedia of Nanotechnology. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9751-4_410
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DOI: https://doi.org/10.1007/978-90-481-9751-4_410
Publisher Name: Springer, Dordrecht
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