Abstract
Even if the reader has only browsed through the previous chapters, he ought to have received my feeling that ozone has an enormous therapeutic potential that, so far, has been either disregarded, if not obstructed by world medical authorities. Reasons for delaying the use of ozone are multiple: while quacks and inexpert ozonetherapists are at fault for poor work, other aspects such as commercial and pharmaceutical interests, prejudice, lack of knowledge and a myopic medical vision have done their best to block a substantial and rapid progress.
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Abraham, N. G., Drummond, G. S., Lutton, J. D., and Kappas, A., 1996, The biological significance and physiological role of heme oxygenase, Cell. Physiol. Biochem. 6:129–168.
Aicher, A., Heeschen, C., Mildner-Rihm, C., Urbich, C., Ihling, C., Technau-Ihling, K., Zeiher, A. M., and Dimmeler, S., 2003, Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells, Natl. Med. 9:1370–1376.
Amersi, F., Buelow, R., Kato, H., Ke, B., Coito, A. J., Shen, X. D., Zhao, D., Zaky, J., Melinek, J., Lassman, C. R., Kolls, J. K., Alam, J., Ritter, T., Volk, H. D., Farmer, D. G., Ghobrial, R. M., Busuttil, R. W., and Kupiec-Weglinski, J. W., 1999, Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury, J. Clin. Invest. 104:1631–1639.
Ames, B. N., 2004, A role for supplements in optimizing health: the metabolic tune-up, Arch. Biochem. Biophys. 423:227–234.
Barakat, S., Seif-El Nasr, A., Ardel-Maksoud, N., El-Ebiary, F., Amer, H., Zaghloul, A., and Thabet, S., 2004, Induktion der angiogenese durch medizinisches ozon, in Ozon-Handbuch Grundlagen Pravention Therapie (R. Viebahn-Hansler, and H. G. Knoch, Eds.), Ecomed, Landsberg: in press.
Barber, E., Menéndez, S., León, O. S., Barber, M. O., Merino, N., Calunga, J. L., Cruz, E., and Bocci, V., 1999, Prevention of renal injury after induction of ozone tolerance in rats submitted to warm ischaemia, Mediators Inflamm. 8:37–41.
Baykal, Y., Yilmaz, M. I., Celik, T., Gok, F., Rehber, H., Akay, C., and Kocar, I. H., 2003, Effects of antihypertensive agents, alpha receptor blockers, beta blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and calcium channel blockers, on oxidative stress, J. Hypertens. 21:1207–1211.
Belluzzi, A., Brignola, C., Campieri, M., Pera, A., Boschi, S., and Miglioli, M., 1996, Effect of an enteric-coated fish-oil preparation on relapses in Crohn’s disease, N. Engl. J. Med. 334:1557–1560.
Bender, D. A., 2002, Daily doses of multivitamin tablets, BMJ 325:173–174.
Bocci, V., 1996a, Does ozone therapy normalize the cellular redox balance? Med. Hypotheses 46:150–154.
Bocci, V., 1996c, Ozone: a mixed blessing. New mechanisms of the action of ozone on blood cells make ozonated major autohaemotherapy (MAH) a rational approach, Forsch. Komplementärmed. 3:25–33.
Bocci, V., 2000, Ossigeno-ozono terapia, Casa Editrice Ambrosiana, Milano, pp. 1–324.
Bocci, V., 2002, Oxygen-ozone therapy, a critical evaluation, Kluwer Academic Publischer, Dordrecht.
Bocci, V., 2007 Può l’Ossigeno-Ozonoterapia migliorare la prognosi della bronco-pneumopatia cronica ostruttiva? Giorn. Ital. Mal. Tor. 61:434–446.
Bocci, V., and Paulesu, L., 1990, Studies on the biological effects of ozone 1. Induction of interferon gamma on human leucocytes, Haematologica 75:510–515.
Borrego, A., Zamora, Z. B., Gonzalez, R., Romay, C., Menendez, S., Hernandez, F., Montero, T., and Rojas, E., 2004, Protection by ozone preconditioning is mediated by the antioxidant system in cisplatin-induced nephrotoxicity in rats, Mediators Inflamm. 13:13–19.
Bridgeman, M. M., Marsden, M., MacNee, W., Flenley, D. C., and Ryle, A. P., 1991, Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine, Thorax 46:39–42.
Brouard, S., Otterbein, L. E., Anrather, J., Tobiasch, E., Bach, F. H., Choi, A. M., and Soares, M. P., 2000, Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis, J. Exp. Med. 192:1015–1026.
Calabrese, E. J., 2002, Hormesis: changing view of the dose-response, a personal account of the history and current status, Mutat. Res. 511:181–189.
Calabrese, E. J., and Baldwin, L. A., 2001, Hormesis: U-shaped dose responses and their centrality in toxicology, Trends Pharmacol. Sci. 22:285–291.
Calabrese, E. J., 2009, Getting the dose-response wrong: why hormesis became marginalized and the threshold model accepted, Arch. Toxicol. 83:227–247.
Cardile, V., Jiang, X., Russo, A., Casella, F., Renis, M., and Bindoni, M., 1995, Effects of ozone on some biological activities of cells in vitro, Cell Biol. Toxicol. 11:11–21.
Chen, Z., Oberley, T. D., Ho, Y., Chua, C. C., Siu, B., Hamdy, R. C., Epstein, C. J., and Chua, B. H., 2000, Overexpression of CuZnSOD in coronary vascular cells attenuates myocardial ischemia/reperfusion injury, Free Radic. Biol. Med. 29:589–596.
Choi, B. M., Pae, H. O., Kim, Y. M., and Chung, H. T., 2003, Nitric oxide-mediated cytoprotection of hepatocytes from glucose deprivation-induced cytotoxicity: involvement of heme oxygenase-1, Hepatology 37:810–823.
Christian, D. L., Chen, L. L., Scannell, C. H., Ferrando, R. E., Welch, B. S., and Balmes, J. R., 1998, Ozone-induced inflammation is attenuated with multiday exposure, Am. J. Respir. Crit. Care Med. 158:532–537.
Clinton, S. K., 1998, Lycopene: chemistry, biology, and implications for human health and disease, Nutr. Rev. 56:35–51.
Csonka, C., Pataki, T., Kovacs, P., Muller, S. L., Schroeter, M. L., Tosaki, A., and Blasig, I. E., 2000, Effects of oxidative stress on the expression of antioxidative defense enzymes in spontaneously hypertensive rat hearts, Free Radic. Biol. Med. 29:612–619.
Csonka, C., Varga, E., Kovacs, P., Ferdinandy, P., Blasig, I. E., Szilvassy, Z., and Tosaki, A., 1999, Heme oxygenase and cardiac function in ischemic/reperfused rat hearts, Free Radic. Biol. Med. 27:119–126.
Das, U. N., 2003, Folic acid says NO to vascular diseases, Nutrition 19:686–692.
Di Paolo, N., Bocci, V., Salvo, D. P. et al., 2005, Extracorporeal blood oxygenation and ozonation (EBOO). A controlled trial in patients with peripheral artery disease, Int. J. Artif. Organs 28:1039–1050.
Dong, Z., Lavrovsky, Y., Venkatachalam, M. A., and Roy, A. K., 2000, Heme oxygenase-1 in tissue pathology: the Yin and Yang, Am. J. Pathol. 156:1485–1488.
Doroshow, J. H., 1995, Glutathione peroxidase and oxidative stress, Toxicol. Lett. 82/83:395–398.
Durante, W., 2003, Heme oxygenase-1 in growth control and its clinical application to vascular disease, J. Cell Physiol. 195:373–382.
Enwonwu, J. W., 1989, Increased metabolic demand for arginine in sickle cell anemia, Med. Sci. Res. 17:997–998.
Farquharson, C. A., Butler, R., Hill, A., Belch, J. J., and Struthers, A. D., 2002, Allopurinol improves endothelial dysfunction in chronic heart failure, Circulation 106:221–226.
Fontana, L., McNeill, K. L., Ritter, J. M., and Chowienczyk, P. J., 1999, Effects of vitamin C and of a cell permeable superoxide dismutase mimetic on acute lipoprotein induced endothelial dysfunction in rabbit aortic rings, Br. J. Pharmacol. 126:730–734.
Fontana, L., Meyer, T. E., Klein, S., and Holloszy, J. O., 2004, Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans, Proc. Natl. Acad. Sci. USA 101:6659–6663.
Forman, H. J., Fukuto, J. M., Miller, T. et al., 2008, The chemistry of cell signalling by reactive oxygen and nitrogen species and 4-hydroxynonenal, Arch. Biochem. Biophys. 477:183–195.
Galbraith, R., 1999, Heme oxygenase: who needs it? Proc. Soc. Exp. Biol. Med. 222:299–305.
Goldman, M., 1996, Cancer risk of low-level exposure, Science 271:1821–1822.
Hack, V., Breitkreutz, R., Kinscherf, R., Rohrer, H., Bartsch, P., Taut, F., Benner, A., and Droge, W., 1998, The redox state as a correlate of senescence and wasting and as a target for therapeutic intervention, Blood 92:59–67.
Halliwell, B., 1999a, Antioxidant defence mechanisms: from the beginning to the end (of the beginning), Free Radic. Res. 31:261–272.
Halliwell, B., 1999b, Vitamin C: poison, prophylactic or panacea? Trends Biochem. Sci. 24:255–259.
Heng, H., Rucker, R. B., Crotty, J., and Dubick, M. A., 1987, The effects of ozone on lung, heart, and liver superoxide dismutase and glutathione peroxidase activities in the protein-deficient rat, Toxicol. Lett. 38:225–237.
Hennekens, C. H., Buring, J. E., and Peto, R., 1994, Antioxidant vitamins – benefits not yet proved, N. Engl. J. Med. 330:1080–1081.
Hernandez, F., Menendez, S., and Wong, R., 1995, Decrease of blood cholesterol and stimulation of antioxidative response in cardiopathy patients treated with endovenous ozone therapy, Free Radic. Biol. Med. 19:115–119.
Jacobson, M. D., 1996, Reactive oxygen species and programmed cell death, Trends Biochem. Sci. 21:83–86.
Jolly, C., and Morimoto, R. I., 2000, Role of the heat shock response and molecular chaperones in oncogenesis and cell death, J. Natl. Cancer Inst. 92:1564–1572.
Jornot, L., Mirault, M. E., and Junod, A. F., 1991, Differential expression of hsp70 stress proteins in human endothelial cells exposed to heat shock and hydrogen peroxide, Am. J. Respir. Cell Mol. Biol. 5:265–275.
Joyner, M. J., and Dietz, N. M., 1997, Nitric oxide and vasodilation in human limbs, J. Appl. Physiol. 83:1785–1796.
Kang, H. J., Kim, H. S., Zhang, S. Y., Park, K. W., Cho, H. J., Koo, B. K., Kim, Y. J., Soo Lee, D., Sohn, D. W., Han, K. S., Oh, B. H., Lee, M. M., and Park, Y. B., 2004, Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial, Lancet 363:751–756.
Kashiba, M., Kasahara, E., Chien, K. C., and Inoue, M., 1999, Fates and vascular action of S-nitrosoglutathione and related compounds in the circulation, Arch. Biochem. Biophys. 363:213–218.
Katano, H., Pesnicak, L., and Cohen, J. I., 2004, Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas, Proc, Natl. Acad. Sci. USA 101:4960–4965.
Kiang, J. G., and Tsokos, G. C., 1998, Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology, Pharmacol. Ther. 80:183–201.
Kume, M., Yamamoto, Y., Saad, S., Gomi, T., Kimoto, S., Shimabukuro, T., Yagi, T., Nakagami, M., Takada, Y., Morimoto, T., and Yamaoka, Y., 1996, Ischemic preconditioning of the liver in rats: implications of heat shock protein induction to increase tolerance of ischemia-reperfusion injury, J. Lab. Clin. Med. 128:251–258.
Lambeth, J. D., 2004, NOX enzymes and the biology of reactive oxygen, Nat. Rev. Immunol. 4:181–189.
León, O. S., Menéndez, S., Merino, N., Castillo, R., Sam, S., Pérez, L., Cruz, E., and Bocci, V., 1998, Ozone oxidative preconditioning: a protection against cellular damage by free radicals, Mediators Inflamm. 7:289–294.
Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R. W., Washko, P. W., Dhariwal, K. R., Park, J. B., Lazarev, A., Graumlich, J. F., King, J., and Cantilena, L. R., 1996, Vitamin C pharmacokinetics in health volunteers: evidence for a recommended dietary allowance, Proc. Natl. Acad. Sci. USA 93:3704–3709.
Liao, J. K., 2002, Isoprenoids as mediators of the biological effects of statins, J. Clin. Invest. 110:285–288.
Llevadot, J., Murasawa, S., Kureishi, Y., Uchida, S., Masuda, H., Kawamoto, A., Walsh, K., Isner, J. M., and Asahara, T., 2001, HMG-CoA reductase inhibitor mobilizes bone marrow – derived endothelial progenitor cells, J. Clin. Invest. 108:399–405.
Madej, P., Plewka, A., Madej, J. A. et al., 2007, Ozone therapy in induced endotoxemic shock. II. The effect of Ozone therapy upon selected histochemical reactions on organs of rats in endotoxemic shock, Inflammation 30:69–86.
McCall, M. R., and Frei, B., 1999, Can antioxidant vitamins materially reduce oxidative damage in humans? Free Radic. Biol. Med. 26:1034–1053.
Miyazono, M., Garat, C., Morris, K. G., Jr., and Carter, E. P., 2002, Decreased renal heme oxygenase-1 expression contributes to decreased renal function during cirrhosis, Am. J. Physiol. Renal. Physiol. 283:F1123–F1131.
Mori, T. A., Woodman, R. J., Burke, V., Puddey, I. B., Croft, K. D., and Beilin, L. J., 2003, Effect of eicosapentaenoic acid and docosahexaenoic acid on oxidative stress and inflammatory markers in treated-hypertensive type 2 diabetic subjects, Free Radic. Biol. Med. 35:772–781.
Morris, C. R., Kuypers, F. A., Larkin, S., Sweeters, N., Simon, J., Vichinsky, E. P., and Styles, L. A., 2000, Arginine therapy: a novel strategy to induce nitric oxide production in sickle cell disease, Br. J. Haematol. 111:498–500.
Murry, C. E., Jennings, R. B., and Reimer, K. A., 1986, Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium, Circulation 74:1124–1136.
Nath, K. A., Haggard, J. J., Croatt, A. J., Grande, J. P., Poss, K. D., and Alam, J., 2000, The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo, Am. J. Pathol. 156:1527–1535.
Noguchi, P., 2003, Risks and benefits of gene therapy, N. Engl. J. Med. 348:193–194.
Olivieri, G., Bodycote, J., and Wolff, S., 1984, Adaptive response of human lymphocytes to low concentrations of radioactive thymidine, Science 223:594–597.
Orlic, D., Kajstura, J., Chimenti, S., Limana, F., Jakoniuk, I., Quaini, F., Nadal-Ginard, B., Bodine, D. M., Leri, A., and Anversa, P., 2001, Mobilized bone marrow cells repair the infarcted heart, improving function and survival, Proc. Natl. Acad. Sci. USA 98:10344–10349.
Packer, L., Roy, S., and Sen, C. K., 1997, Alpha-lipoic acid: a metabolic antioxidant and potential redox modulator of transcription, Adv. Pharmacol. 38:79–101.
Peng, J., Jones, G. L., and Watson, K., 2000, Stress proteins as biomarkers of oxidative stress: effects of antioxidant supplements, Free Radic. Biol. Med. 28:1598–1606.
Peralta, C., Leon, O. S., Xaus, C., Prats, N., Jalil, E. C., Planell, E. S., Puig-Parellada, P., Gelpi, E., and Rosello-Catafau, J., 1999, Protective effect of ozone treatment on the injury associated with hepatic ischemia-reperfusion: antioxidant-prooxidant balance, Free Radic. Res. 31:191–196.
Peralta, C., Xaus, C., Bartrons, R., Leon, O. S., Gelpi, E., and Rosello-Catafau, J., 2000, Effect of ozone treatment on reactive oxygen species and adenosine production during hepatic ischemia-reperfusion, Free Radic. Res. 33:595–605.
Polidori, M. C., Mecocci, P., Levine, M., and Frei, B., 2004, Short-term and long-term vitamin C supplementation in humans dose-dependently increases the resistance of plasma to ex vivo lipid peroxidation, Arch. Biochem. Biophys. 423:109–115.
Polidori, M. C., Stahl, W., Eichler, O., Niestroj, I., and Sies, H., 2001, Profiles of antioxidants in human plasma, Free Radic. Biol. Med. 30:456–462.
Pryor, W. A., 2000, Vitamin E and heart disease: basic science to clinical intervention trials, Free Radic. Biol. Med. 28:141–164.
Puskas, F., Gergely, P., Jr., Banki, K., and Perl, A., 2000, Stimulation of the pentose phosphate pathway and glutathione levels by dehydroascorbate, the oxidized form of vitamin C, FASEB J. 14:1352–1361.
Rahman, I., Clerch, L. B., and Massaro, D., 1991, Rat lung antioxidant enzyme induction by ozone, Am. J. Physiol. 260:L412–L418.
Reeve, V. E., and Tyrrell, R. M., 1999, Heme oxygenase induction mediates the photoimmunoprotective activity of UVA radiation in the mouse, Proc. Natl. Acad. Sci. USA 96:9317–9321.
Riksen, N. P., Rongen, G. A., Blom, H. J., Russel, F. G., Boers, G. H., and Smits, P., 2003, Potential role for adenosine in the pathogenesis of the vascular complications of hyperhomocysteinemia, Cardiovasc. Res. 59:271–276.
Roberts, W. C., 1996, The underused miracle drugs: the statin drugs are to atherosclerosis what penicillin was to infectious disease, Am, J. Cardiol. 78:377–378.
Ryter, S. W., and Tyrrell, R. M., 2000, The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties, Free Radic. Biol. Med. 28:289–309.
Sagara, Y., Dargusch, R., Chambers, D., Davis, J., Schubert, D., and Maher, P., 1998, Cellular mechanisms of resistance to chronic oxidative stress, Free Radic. Biol. Med. 24:1375–1389.
Sato, K., Balla, J., Otterbein, L., Smith, R. N., Brouard, S., Lin, Y., Csizmadia, E., Sevigny, J., Robson, S. C., Vercellotti, G., Choi, A. M., Bach, F. H., and Soares, M. P., 2001, Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants, J. Immunol. 166:4185–4194.
Schwartz, R. S., and Curfman, G. D., 2002, Can the heart repair itself? N. Engl. J. Med. 346:2–4.
Seifried, H. E., McDonald, S. S., Anderson, D. E., Greenwald, P., and Milner, J. A., 2003, The antioxidant conundrum in cancer, Cancer Res. 63:4295–4298.
Shull, S., Heintz, N. H., Periasamy, M., Manohar, M., Janssen, Y. M. W., Marsh, J. P., and Mossman, B. T., 1991, Differential regulation of antioxidant enzymes in response to oxidants, J. Biol. Chem. 266:24398–24403.
Snyder, S. H., and Baranano, D. E., 2001, Heme oxygenase: a font of multiple messengers, Neuropsychopharmacology 25:294–298.
Spencer, F. A., Allegrone, J., Goldberg, R. J., Gore, J. M., Fox, K. A., Granger, C. B., Mehta, R. H., and Brieger, D., 2004, Association of statin therapy with outcomes of acute coronary syndromes: the GRACE study, Ann. Intern. Med. 140:857–866.
Stadlbauer, T. H. W., Eisele, A., Heidt, M. C. et al., 2008, Preconditioning with ozone abrogates acute rejection and prolongs cardiac allograft survival in rats, Transplant. Proc. 40:974–977.
Stamler, J. S., 2004, S-nitrosothiols in the blood: roles, amounts, and methods of analysis, Circ. Res. 94:414–417.
Strauer, B. E., and Kornowski, R., 2003, Stem cell therapy in perspective, Circulation 107:929–934.
Strauer, B. E., Brehm, M., Zeus, T., Gattermann, N., Hernandez, A., Sorg, R. V., Kogler, G., and Wernet, P., 2001, Intracoronary, human autologous stem cell transplantation for myocardial regeneration following myocardial infarction, Dtsch. Med. Wochenschr 126:932–938.
Su, W. Y., and Gordon, T., 1997, In vivo exposure to ozone produces an increase in a 72-kDa heat shock protein in guinea pigs, J. Appl. Physiol. 83:707–711.
Sun, J. S., Lu, F. J., Huang, W. C., Hou, S. M., Tsuang, Y. H., and Hang, Y. S., 1999, Antioxidant status following acute ischemic limb injury: a rabbit model, Free Radic. Res. 31:9–21.
Tacchini, L., Pogliaghi, G., Radice, L., Bernelli-Zazzera, A., and Cairo, G., 1996, Post-transcriptional control of increased hepatic catalase gene expression in response to oxidative stress, Redox Report 2:273–278.
Tepel, M., van der, G. M., Statz, M., Jankowski, J., and Zidek, W., 2003, The antioxidant acetylcysteine reduces cardiovascular events in patients with end-stage renal failure: a randomized, controlled trial, Circulation 107:992–995.
Topol, E. J., 2004, Intensive statin therapy – a sea change in cardiovascular prevention, N. Engl. J. Med. 350:1562–1564.
Vasiliou, V., Pappa, A., and Petersen, D. R., 2000, Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism, Chem. Biol. Interact. 129:1–19.
Victor, V. M., McCreath, K. J., and Rocha, M., 2006, Recent progress in pharmacological research of antioxidants in pathological conditions, cardiovascular health, Recent Pat. Antinfect. Drug Discov. 1:17–31.
Vivekananthan, D. P., Penn, M. S., Sapp, S. K., Hsu, A., and Topol, E. J., 2003, Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials, Lancet 361:2017–2023.
Vollmer, T., Key, L., Durkalski, V., Tyor, W., Corboy, J., Markovic-Plese, S., Preiningerova, J., Rizzo, M., and Singh, I., 2004, Oral simvastatin treatment in relapsing-remitting multiple sclerosis, Lancet 363:1607–1608.
von Harsdorf, R., Poole-Wilson, P. A., and Dietz, R., 2004, Regenerative capacity of the myocardium: implications for treatment of heart failure, Lancet 363:1306–1313.
Wadhwa, P. D., Zielske, S. P., Roth, J. C., Ballas, C. B., Bowman, J. E., and Gerson, S. L., 2002, Cancer gene therapy: scientific basis, Annu. Rev. Med. 53:437–452.
Wagner, M., Cadetg, P., Ruf, R., Mazzucchelli, L., Ferrari, P., and Redaelli, C. A., 2003, Heme oxygenase-1 attenuates ischemia/reperfusion-induced apoptosis and improves survival in rat renal allografts, Kidney Int. 63:1564–1573.
Wang, P., Chen, H., Qin, H., Sankarapandi, S., Becher, M. W., Wong, P. C., and Zweier, J. L., 1998, Overexpression of human copper, zinc-superoxide dismutase (SOD1) prevents postischemic injury, Proc. Natl. Acad. Sci. USA 95:4556–4560.
Wolff, S., 1996, Aspects of the adaptive response to very low doses of radiation and other agents, Mutat. Res. 358:135–142.
Yamamoto, H., Yamamoto, Y., Yamagami, K., Kume, M., Kimoto, S., Toyokuni, S., Uchida, K., Fukumoto, M., and Yamaoka, Y., 2000, Heat-shock preconditioning reduces oxidative protein denaturation and ameliorates liver injury by carbon tetrachloride in rats, Res. Exp. Med. (Berl) 199:309–318.
Zino, S., Skeaff, M., Williams, S., and Mann, J., 1997, Randomised controlled trial of effect of fruit and vegetable consumption on plasma concentrations of lipids and antioxidants, BMJ 314:1787–1791.
Zuckerbraun, B. S., and Billiar, T. R., 2003, Heme oxygenase-1: a cellular Hercules, Hepatology 37:742–744.
Seixas, E., Gozzelino, R., Chora, A., et al., 2009, Heme oxygenase-1 affords protection against noncerebral forms of severe malaria. Proc. Natl. Acad. Sci. USA 106:15837–15842.
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Bocci, V. (2010). Is Ozone Really a “Wonder Drug”?. In: OZONE. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9234-2_8
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