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The Effect of Secoisolariciresinol on 3t3-L1 Adipocytes and the Relationship Between Molecular Structure and the Activity

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Animal Cell Technology: Basic & Applied Aspects

Part of the book series: Animal Cell Technology: Basic & Applied Aspects ((ANICELLTECH,volume 16))

Abstract

Secoisolariciresinol (SECO) is one of the lignans contained in flaxseed. SECO has some stereoisomeric forms, and they exist as the racemic form in flaxseed. Therefore, we stereoselectively synthesized (+)-SECO, (–)-SECO, and meso-SECO forms. In this study, we focused on the effects of SECOs on the regulation of 3T3-L1 adipocytes, and revealed the structure-activity relationships. As a result, (–)-SECO accelerated adiponectin production of 3T3-L1 adipocytes by enhancement of adiponectin mRNA transcription activity in the cells. On the other hand, (+)- and meso-SECO suppressed. In addition, triglyceride accumulation in 3T3-L1 adipocytes was significantly suppressed by all three SECOs when each SECO was added to the medium during induction of 3T3-L1 preadipocytes to matured adipocytes.

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References

  1. Fukumitsu, S., Aida, K., Ueno, N., Ozawa, S., Takahashi, Y., and Kobori, M. (2008) Flaxseed lignan attenuates high-fat diet-induced fat accumulation and induces adiponectin expression in mice. Br. J. Nutr. 100: 1–8.

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Authors and Affiliations

  1. Ehime University, Matsuyama, Ehime, 790-8566, Japan

    Shiori Tominaga, Manami Yamawaki, Yuki Nakashima, Taro Kishida, Masafumi Maruyama & Satoshi Yamauchi

  2. Ehime University, Tarumi, Matsuyama, 790-8566, Japan

    Takuya Sugahara

  3. Center for Marine Environmental Studies (CMES), Ehime University, Matsuyama, Ehime, 790-8577, Japan

    Sogo Nishimoto

  4. Integrated Center for Sciences, Ehime University, Matsuyama, Ehime, 790-8566, Japan

    Koichi Akiyama

  5. Faculty of Agriculture, Ehime University, Matsuyama, Ehime, 790-8566, Japan

    Koichi Akiyama

Authors
  1. Shiori Tominaga
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  2. Takuya Sugahara
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  3. Sogo Nishimoto
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  4. Manami Yamawaki
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  5. Yuki Nakashima
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  6. Taro Kishida
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  7. Koichi Akiyama
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  8. Masafumi Maruyama
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  9. Satoshi Yamauchi
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Corresponding author

Correspondence to Shiori Tominaga .

Editor information

Editors and Affiliations

  1. Fac. Engineering, Dept. Chemical Engineering, Kyushu University, Motooka 744, Fukuoka, 819-0395, Japan

    Masamichi Kamihira

  2. Fac. Agriculture, Kyushu University, Hakozaki 6-10-1, Fukuoka, 812-8581, Japan

    Yoshinori Katakura

  3. Fac. Engineering, Kyushu University, Fukuoka, 819-0395, Japan

    Akira Ito

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© 2010 Springer Science+Business Media B.V.

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Tominaga, S. et al. (2010). The Effect of Secoisolariciresinol on 3t3-L1 Adipocytes and the Relationship Between Molecular Structure and the Activity. In: Kamihira, M., Katakura, Y., Ito, A. (eds) Animal Cell Technology: Basic & Applied Aspects. Animal Cell Technology: Basic & Applied Aspects, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3892-0_57

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