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Beneficial Role of Taurine Against Myocardial Apoptosis During Ischemic Injury

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Apoptosome

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Abstract

Taurine is one of the most abundant free amino acids in the heart, and exerts a number of cytoprotective actions, such as osmoregulation, antioxidant and modulation of calcium movement. Several lines of evidences indicate that taurine treatment is effective against myocardial ischemic disease. Anti-apoptotic effects of taurine have been described in myocardial tissue, which should contribute to the cytoprotective role of taurine against myocardial ischemia and ischemia/reperfusion-induced injury. Recent progresses have clarified a variety of signaling pathway that contribute to the anti-apoptotic actions of taurine during myocardial ischemia. In this chapter, we discuss the potential molecular mechanism underlying the anti-apoptotic role of taurine during myocardial ischemia.

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Authors and Affiliations

  1. Department of Pharmacy, University of Health Sciences, School of Pharmacy, Kobe, Japan

    Takashi Ito & Junichi Azuma

  2. Department of Clinical Pharmacology, University of South Alabama, College of Medicine, Alabama, USA

    Stephen W. Schaffer

Authors
  1. Takashi Ito
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  2. Stephen W. Schaffer
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  3. Junichi Azuma
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Correspondence to Junichi Azuma .

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Editors and Affiliations

  1. Dipto. Biologia, Università di Roma, Tor Vergata, Via della Ricerca Scientifica, Roma, 00133, Italy

    Francesco Cecconi

  2. IRCCS, Fondazione Santa Lucia, Via Fosso di Fiorano, Roma, 00143, Italy

    Marcello D'Amelio

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Ito, T., Schaffer, S.W., Azuma, J. (2010). Beneficial Role of Taurine Against Myocardial Apoptosis During Ischemic Injury. In: Cecconi, F., D'Amelio, M. (eds) Apoptosome. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3415-1_6

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